8-oxocoformycin reductase

In enzymology, a 8-oxocoformycin reductase (EC 1.1.1.235) is an enzyme that catalyzes the chemical reaction

coformycin + NADP⁺ ${\displaystyle \rightleftharpoons }$ 8-oxocoformycin + NADPH + H⁺

Thus, the two substrates of this enzyme are coformycin and NADP⁺, whereas its 3 products are 8-oxocoformycin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is coformycin:NADP⁺ 8-oxidoreductase. This enzyme is also called 8-ketodeoxycoformycin reductase.

References

• Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ (July 1988). "8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin". Biochemistry. 27 (15): 5790–5. doi:10.1021/bi00415a059. PMID 3052586.