CNOT1

Protein-coding gene in the species Homo sapiens
CNOT1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4C0D, 4CQO, 4CRV, 4CRW, 4CT4, 4CT6, 4CT7, 4GMJ, 4GML, 4J8S, 5ANR, 5FU6, 5FU7

Identifiers
AliasesCNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS
External IDsOMIM: 604917; MGI: 2442402; HomoloGene: 9453; GeneCards: CNOT1; OMA:CNOT1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CNOT1
Genomic location for CNOT1
Band16q21Start58,519,951 bp[1]
End58,629,885 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CNOT1
Genomic location for CNOT1
Band8|8 D1Start96,446,079 bp[2]
End96,534,092 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • left testis

  • right testis

  • ventricular zone

  • ganglionic eminence

  • mucosa of transverse colon

  • skin of abdomen

  • skin of leg

  • granulocyte

  • epithelium of colon
Top expressed in
  • tail of embryo

  • genital tubercle

  • spermatocyte

  • ventricular zone

  • spermatid

  • yolk sac

  • neural layer of retina

  • zygote

  • granulocyte

  • morula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • poly(A)-specific ribonuclease activity
  • protein domain specific binding
  • protein binding
  • retinoic acid receptor binding
  • armadillo repeat domain binding
  • molecular adaptor activity
  • estrogen receptor binding
  • RNA binding
Cellular component
  • membrane
  • CCR4-NOT complex
  • peroxisomal membrane
  • P-body
  • CCR4-NOT core complex
  • nucleus
  • extracellular space
  • cytoplasm
  • cytosol
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • negative regulation of translation
  • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription, DNA-templated
  • negative regulation of retinoic acid receptor signaling pathway
  • regulation of stem cell population maintenance
  • negative regulation of transcription by RNA polymerase II
  • positive regulation of mRNA catabolic process
  • transcription, DNA-templated
  • multicellular organism development
  • positive regulation of cytoplasmic mRNA processing body assembly
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • gene silencing by miRNA
  • gene silencing
  • negative regulation of intracellular estrogen receptor signaling pathway
  • regulation of translation
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23019

234594

Ensembl

ENSG00000125107

ENSMUSG00000036550

UniProt

A5YKK6
H3BNB1

Q6ZQ08

RefSeq (mRNA)

NM_001265612
NM_016284
NM_206999

NM_001205226
NM_153164
NM_178078
NM_001372351
NM_001372353

RefSeq (protein)

NP_001252541
NP_057368
NP_996882

NP_001192155
NP_694804
NP_835179
NP_001359280
NP_001359282

Location (UCSC)Chr 16: 58.52 – 58.63 MbChr 8: 96.45 – 96.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
CCR4-Not complex component, Not1
Identifiers
SymbolNot1
PfamPF04054
InterProIPR007196
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[5][6]

It is a part of the CCR4-Not complex, which deadenylates mRNAs.[7] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[8][9][10]

Interactions

CNOT1 has been shown to interact with CNOT8.[11][12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125107 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036550 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  6. ^ "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1".
  7. ^ Garneau NL, Wilusz J, Wilusz CJ (Feb 2007). "The highways and byways of mRNA decay". Nat. Rev. Mol. Cell Biol. 8 (2): 113–26. doi:10.1038/nrm2104. PMID 17245413. S2CID 14107577.
  8. ^ Sandler H, Kreth J, Timmers HT, Stoecklin G (May 2011). "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin". Nucleic Acids Res. 39 (10): 4373–86. doi:10.1093/nar/gkr011. PMC 3105394. PMID 21278420.
  9. ^ Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O (Nov 2012). "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex". Nucleic Acids Res. 40 (21): 11058–72. doi:10.1093/nar/gks883. PMC 3510486. PMID 22977175.
  10. ^ Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E (Oct 26, 2012). "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell. 48 (2): 207–18. doi:10.1016/j.molcel.2012.08.014. PMID 22959269.
  11. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  12. ^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  • Chen J, Rappsilber J, Chiang YC, Russell P, Mann M, Denis CL (2001). "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex". J. Mol. Biol. 314 (4): 683–94. doi:10.1006/jmbi.2001.5162. PMID 11733989.
  • Laveder P, De Pittà C, Toppo S, Valle G, Lanfranchi G (2002). "A two-step strategy for constructing specifically self-subtracted cDNA libraries". Nucleic Acids Res. 30 (9): 38e–38. doi:10.1093/nar/30.9.e38. PMC 113861. PMID 11972353.
  • Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT (2006). "Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription". EMBO J. 25 (13): 3089–99. doi:10.1038/sj.emboj.7601194. PMC 1500986. PMID 16778766.

External links

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