COG1

Protein-coding gene in the species Homo sapiens
COG1
Identifiers
AliasesCOG1, CDG2G, LDLB, component of oligomeric golgi complex 1
External IDsOMIM: 606973; MGI: 1333873; HomoloGene: 8411; GeneCards: COG1; OMA:COG1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for COG1
Genomic location for COG1
Band17q25.1Start73,193,055 bp[1]
End73,208,507 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for COG1
Genomic location for COG1
Band11|11 E2Start113,539,995 bp[2]
End113,557,880 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • apex of heart

  • right frontal lobe

  • anterior pituitary

  • Brodmann area 9

  • nucleus accumbens

  • prefrontal cortex

  • cingulate gyrus

  • anterior cingulate cortex

  • muscle of thigh
Top expressed in
  • external carotid artery

  • internal carotid artery

  • motor neuron

  • substantia nigra

  • islet of Langerhans

  • seminiferous tubule

  • Paneth cell

  • right ventricle

  • paraventricular nucleus of hypothalamus

  • submandibular gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Golgi membrane
  • Golgi apparatus
  • membrane
  • trans-Golgi network membrane
  • Golgi transport complex
Biological process
  • protein transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • intra-Golgi vesicle-mediated transport
  • Golgi organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9382

16834

Ensembl

ENSG00000166685

ENSMUSG00000018661

UniProt

Q8WTW3

Q9Z160

RefSeq (mRNA)

NM_018714

NM_013581

RefSeq (protein)

NP_061184

NP_038609

Location (UCSC)Chr 17: 73.19 – 73.21 MbChr 11: 113.54 – 113.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.[5][6]

The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.[6]

Interactions

COG1 has been shown to interact with COG4[7] and COG3.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018661 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A. 96 (3): 915–20. Bibcode:1999PNAS...96..915C. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.
  6. ^ a b "Entrez Gene: COG1 component of oligomeric golgi complex 1".
  7. ^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23). United States: 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
  8. ^ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24). United States: 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.

Further reading

  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
  • Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex". J. Biol. Chem. 280 (38): 32729–35. doi:10.1074/jbc.M504590200. PMID 16020545.
  • Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex". Exp. Cell Res. 312 (16): 3132–41. doi:10.1016/j.yexcr.2006.06.005. PMID 16857184.

External links

  • GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
  • Human COG1 genome location and COG1 gene details page in the UCSC Genome Browser.


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