Dynorphin A

Dynorphin A^[1]
Names

Other names Dynorphin 1-13
Identifiers
CAS Number	72957-38-1^Y
PubChem CID	16130969
UNII	VFC23V742Z^Y
Properties
Chemical formula	C₇₅H₁₂₆N₂₄O₁₅
Molar mass	1603.95474
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references

Chemical compound

Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor.^[2] Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.

Dynorphin A_1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.^[3]^[4] Dynorphin A_1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;^[4] it has the highest binding affinity for the kappa-opioid receptor.^[4] Structures of dynorphin A bound to the κ-opioid receptor have been reported.^[2]^[5]

References

^ Dynorphin 1-13 - Compound Summary, PubChem.
^ ^a ^b Wang, Yue; Zhuang, Youwen; DiBerto, Jeffrey F.; Zhou, X. Edward; Schmitz, Gavin P.; Yuan, Qingning; Jain, Manish K.; Liu, Weiyi; Melcher, Karsten; Jiang, Yi; Roth, Bryan L.; Xu, H. Eric (2023-01-12). "Structures of the entire human opioid receptor family". Cell. 186 (2): 413–427.e17. doi:10.1016/j.cell.2022.12.026. PMID 36638794. S2CID 255750597.
^ "Dynorphin A 1-8". HMDB Version 4.0. Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017.
^ ^a ^b ^c "Dynorphin A-(1-8): Biological activity". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 20 October 2017. Principal endogenous agonists at κ receptor
^ Chen, Yuxiang; Chen, Bo; Wu, Tingting; Zhou, Fangfang; Xu, Fei (2022-08-05). "Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A". Protein & Cell. 14 (6): 464–468. doi:10.1093/procel/pwac033. ISSN 1674-800X. PMC 10246719. PMID 37285260.

Peptides: neuropeptides

Hormones

see hormones

Opioid peptides

Dynorphins	Dynorphin A Dynorphin A_1–8 Dynorphin B Big dynorphin Leumorphin α-Neoendorphin β-Neoendorphin
Endomorphins	Endomorphin-1 Endomorphin-2
Endorphins	α-Endorphin β-Endorphin γ-Endorphin
Enkephalins	Met-enkephalin Leu-enkephalin
Others	Adrenorphin Amidorphin Hemorphin Hemorphin-4 Nociceptin Opiorphin Spinorphin Valorphin

Other
neuropeptides

Kinins	Bradykinins Tachykinins: mammal Substance P Neurokinin A Neurokinin B amphibian Kassinin Physalaemin
Neuromedins	B N S U
Orexins	A B
Other	Angiotensin Bombesin Calcitonin gene-related peptide Carnosine Cocaine- and amphetamine-regulated transcript Delta-sleep-inducing peptide FMRFamide Galanin Galanin-like peptide Gastrin-releasing peptide Ghrelin Neuropeptide AF Neuropeptide FF Neuropeptide SF Neuropeptide VF Neuropeptide S Neuropeptide Y Neurophysins Neurotensin Pancreatic polypeptide Pituitary adenylate cyclase-activating peptide RVD-Hpα VGF