ELL3

Protein-coding gene in the species Homo sapiens
ELL3
Identifiers
AliasesELL3, ELL3 (gene), elongation factor for RNA polymerase II 3
External IDsOMIM: 609885; MGI: 2673679; HomoloGene: 11859; GeneCards: ELL3; OMA:ELL3 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ELL3
Genomic location for ELL3
Band15q15.3Start43,772,605 bp[1]
End43,777,315 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ELL3
Genomic location for ELL3
Band2|2 E5Start121,269,491 bp[2]
End121,274,759 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • duodenum

  • lymph node

  • zone of skin

  • skin of abdomen

  • rectum

  • appendix

  • thymus

  • vagina

  • cerebellar hemisphere

  • minor salivary glands
Top expressed in
  • spleen

  • morula

  • proximal tubule

  • kidney

  • zone of skin

  • yolk sac

  • blastocyst

  • secondary oocyte

  • respiratory epithelium

  • lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleolus
  • transcription elongation factor complex
  • nucleus
  • nucleoplasm
Biological process
  • positive regulation of DNA-templated transcription, elongation
  • positive regulation of neurogenesis
  • positive regulation of neural precursor cell proliferation
  • transcription elongation from RNA polymerase II promoter
  • regulation of epithelial to mesenchymal transition
  • DNA-templated transcription, elongation
  • regulation of transcription, DNA-templated
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • transcription by RNA polymerase II
  • spermatogenesis
  • positive regulation of transcription by RNA polymerase II
  • stem cell differentiation
  • transcription, DNA-templated
  • negative regulation of signal transduction by p53 class mediator
  • snRNA transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80237

269344

Ensembl

ENSG00000128886

ENSMUSG00000027246

UniProt

Q9HB65

Q80VR2

RefSeq (mRNA)

NM_025165

NM_145973

RefSeq (protein)

NP_079441

NP_666085

Location (UCSC)Chr 15: 43.77 – 43.78 MbChr 2: 121.27 – 121.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128886 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027246 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Elongation factor RNA polymerase II-like 3".

Further reading

  • Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP, Florens L, Seidel CW, Lin C, Smith ER, Shilatifard A, Conaway RC, Conaway JW (July 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92–104. doi:10.1016/j.cell.2011.06.005. PMC 3145325. PMID 21729782.
  • Park G, Gong Z, Chen J, Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10.1007/s10930-010-9242-8. PMID 20431927. S2CID 38143958.
  • Miller T, Williams K, Johnstone RW, Shilatifard A (October 2000). "Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3". The Journal of Biological Chemistry. 275 (41): 32052–6. doi:10.1074/jbc.M005175200. PMID 10882741.
  • Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (May 2009). "Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins". Proteomics. 9 (9): 2444–56. doi:10.1002/pmic.200800738. PMID 19343720. S2CID 22613066.
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