EML4

Protein-coding gene in the species Homo sapiens
EML4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4CGC

Identifiers
AliasesEML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
External IDsOMIM: 607442; MGI: 1926048; HomoloGene: 56841; GeneCards: EML4; OMA:EML4 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for EML4
Genomic location for EML4
Band2p21Start42,169,353 bp[1]
End42,332,548 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for EML4
Genomic location for EML4
Band17|17 E4Start83,658,360 bp[2]
End83,787,790 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • jejunal mucosa

  • visceral pleura

  • thymus

  • duodenum

  • rectum

  • pylorus

  • spleen

  • parotid gland

  • lymph node
Top expressed in
  • hand

  • maxillary prominence

  • molar

  • primitive streak

  • abdominal wall

  • secondary oocyte

  • renal corpuscle

  • medullary collecting duct

  • ciliary body

  • otolith organ
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • molecular function
Cellular component
  • cytoplasm
  • microtubule
  • cytoskeleton
  • membrane
  • microtubule cytoskeleton
  • mitotic spindle
Biological process
  • microtubule-based process
  • mitotic cell cycle
  • microtubule cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27436

78798

Ensembl

ENSG00000143924

ENSMUSG00000032624

UniProt

Q9HC35

Q3UMY5

RefSeq (mRNA)

NM_001145076
NM_019063

NM_001114361
NM_001114362
NM_001286567
NM_199466
NM_001357886

NM_001379373
NM_001379374

RefSeq (protein)

NP_001138548
NP_061936

NP_001107833
NP_001107834
NP_001273496
NP_955760
NP_001344815

NP_001366302
NP_001366303

Location (UCSC)Chr 2: 42.17 – 42.33 MbChr 17: 83.66 – 83.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.[5]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143924 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032624 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
  6. ^ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Heidebrecht HJ, Buck F, Pollmann M, et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein". Genomics. 68 (3): 348–50. doi:10.1006/geno.2000.6301. PMID 10995578.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Pollmann M, Parwaresch R, Adam-Klages S, et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation". Exp. Cell Res. 312 (17): 3241–51. doi:10.1016/j.yexcr.2006.06.035. PMID 16890222.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9HC35 (Human Echinoderm microtubule-associated protein-like 4 (EML4)) at the PDBe-KB.
  • v
  • t
  • e
Echinoderm microtubule-associated protein-like proteins
  • EML1
  • EML2
  • EML3
  • EML4
  • EML5
  • EML6


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