FKBP8

Protein-coding gene in the species Homo sapiens
FKBP8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2AWG, 2D9F, 2F2D, 2MF9, 3EY6

Identifiers
AliasesFKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
External IDsOMIM: 604840; MGI: 1341070; HomoloGene: 7720; GeneCards: FKBP8; OMA:FKBP8 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for FKBP8
Genomic location for FKBP8
Band19p13.11Start18,531,751 bp[1]
End18,544,077 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for FKBP8
Genomic location for FKBP8
Band8|8 B3.3Start70,980,374 bp[2]
End70,987,978 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • right testis

  • left testis

  • right hemisphere of cerebellum

  • anterior pituitary

  • C1 segment

  • cingulate gyrus

  • anterior cingulate cortex

  • muscle layer of sigmoid colon

  • right uterine tube
Top expressed in
  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • spermatocyte

  • neural layer of retina

  • granulocyte

  • lip

  • perirhinal cortex

  • entorhinal cortex

  • ventricular zone
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • FK506 binding
  • isomerase activity
  • peptidyl-prolyl cis-trans isomerase activity
  • metal ion binding
  • protein binding
  • identical protein binding
  • disordered domain specific binding
Cellular component
  • integral component of membrane
  • membrane
  • mitochondrial membranes
  • integral component of endoplasmic reticulum membrane
  • mitochondrial envelope
  • mitochondrion
  • endoplasmic reticulum
  • cytosol
  • cytoplasm
  • protein-containing complex
Biological process
  • apoptotic process
  • intracellular signal transduction
  • multicellular organism growth
  • cell fate specification
  • negative regulation of apoptotic process
  • regulation of BMP signaling pathway
  • neural tube development
  • positive regulation of BMP signaling pathway
  • regulation of gene expression
  • smoothened signaling pathway
  • camera-type eye development
  • dorsal/ventral neural tube patterning
  • viral process
  • dorsal/ventral pattern formation
  • chaperone-mediated protein folding
  • protein peptidyl-prolyl isomerization
  • negative regulation of protein phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23770

14232

Ensembl

ENSG00000105701

ENSMUSG00000019428

UniProt

Q14318

O35465

RefSeq (mRNA)

NM_001308373
NM_012181

NM_001111066
NM_001199631
NM_010223

RefSeq (protein)

NP_001295302
NP_036313
NP_001295302.1

NP_001104536
NP_001186560
NP_034353

Location (UCSC)Chr 19: 18.53 – 18.54 MbChr 8: 70.98 – 70.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.[5][6]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105701 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019428 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.
  6. ^ a b "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Pedersen KM, Finsen B, Celis JE, Jensen NA (1999). "muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo". Electrophoresis. 20 (2): 249–55. doi:10.1002/(SICI)1522-2683(19990201)20:2<249::AID-ELPS249>3.0.CO;2-F. PMID 10197430. S2CID 23007045.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shirane M, Nakayama KI (2003). "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis". Nat. Cell Biol. 5 (1): 28–37. doi:10.1038/ncb894. PMID 12510191. S2CID 11653096.
  • Rosner M, Hofer K, Kubista M, Hengstschläger M (2003). "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38". Oncogene. 22 (31): 4786–98. doi:10.1038/sj.onc.1206776. PMID 12894220.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Bulgakov OV, Eggenschwiler JT, Hong DH, et al. (2004). "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues". Development. 131 (9): 2149–59. doi:10.1242/dev.01122. PMID 15105374. S2CID 8203913.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Kang CB, Tai J, Chia J, Yoon HS (2005). "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)". FEBS Lett. 579 (6): 1469–76. doi:10.1016/j.febslet.2005.01.053. hdl:10356/95126. PMID 15733859. S2CID 19114701.
  • Weiwad M, Edlich F, Erdmann F, et al. (2005). "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin". FEBS Lett. 579 (7): 1591–6. doi:10.1016/j.febslet.2004.12.098. PMID 15757646. S2CID 12995306.
  • Edlich F, Weiwad M, Erdmann F, et al. (2005). "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin". EMBO J. 24 (14): 2688–99. doi:10.1038/sj.emboj.7600739. PMC 1176465. PMID 15990872.
  • Kang CB, Feng L, Chia J, Yoon HS (2005). "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2". Biochem. Biophys. Res. Commun. 337 (1): 30–8. doi:10.1016/j.bbrc.2005.09.023. hdl:10356/94816. PMID 16176796.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • v
  • t
  • e
  • 2awg: Structure of the PPIase domain of the Human FK506-binding protein 8
    2awg: Structure of the PPIase domain of the Human FK506-binding protein 8
  • 2d9f: Solution structure of RUH-047, an FKBP domain from human cDNA
    2d9f: Solution structure of RUH-047, an FKBP domain from human cDNA
  • 2f2d: Solution structure of the FK506-binding domain of human FKBP38
    2f2d: Solution structure of the FK506-binding domain of human FKBP38
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