Fenleuton
5-lipoxygenase inhibitor
- none
- 1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea
- 141579-54-6
- 65045
- LG64454O6I
- D04151
- DTXSID40869916
- Interactive image
- CC(C#Cc1cccc(c1)Oc2ccc(cc2)F)N(C(=O)N)O
InChI
- InChI=InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
- Key:MWXPQCKCKPYBDR-UHFFFAOYSA-N[1]
Fenleuton (trade name Lofrin) is a drug that acts as a 5-lipoxygenase inhibitor and inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. It has been studied for potential use in veterinary medicine to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) in horses.[2]
References
- ^ "1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015.
- ^ Marr KA, Lees P, Page CP, Cunningham FM (1998). "Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease". J Vet Pharmacol Ther. 21 (3): 241–246. doi:10.1046/j.1365-2885.1998.00127.x. PMID 9673966.
- v
- t
- e
(ligands)
BLTTooltip Leukotriene B4 receptor |
| ||||||
---|---|---|---|---|---|---|---|
CysLTTooltip Cysteinyl leukotriene receptor |
|
(inhibitors)
5-LOXTooltip Arachidonate 5-lipoxygenase |
|
---|---|
12-LOXTooltip Arachidonate 12-lipoxygenase |
|
15-LOXTooltip Arachidonate 15-lipoxygenase |
|
LTA4HTooltip Leukotriene A4 hydrolase |
|
LTB4HTooltip Leukotriene B4 ω-hydroxylase |
|
LTC4STooltip Leukotriene C4 synthase | |
LTC4HTooltip Leukotriene C4 hydrolase |
|
LTD4Tooltip Leukotriene D4 hydrolase |
- See also
- Receptor/signaling modulators
- Prostanoid signaling modulators
This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e