GRIN3B

Protein-coding gene in the species Homo sapiens
GRIN3B
Identifiers
AliasesGRIN3B, GluN3B, NR3B, glutamate ionotropic receptor NMDA type subunit 3B
External IDsOMIM: 606651; MGI: 2150393; HomoloGene: 15606; GeneCards: GRIN3B; OMA:GRIN3B - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GRIN3B
Genomic location for GRIN3B
Band19p13.3Start1,000,419 bp[1]
End1,009,732 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for GRIN3B
Genomic location for GRIN3B
Band10|10 C1Start79,806,549 bp[2]
End79,813,024 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • bronchial epithelial cell

  • stromal cell of endometrium

  • right lung

  • canal of the cervix

  • left lobe of thyroid gland

  • spleen

  • anterior pituitary

  • tibial nerve

  • right lobe of thyroid gland
Top expressed in
  • motor neuron

  • facial motor nucleus

  • spermatid

  • seminiferous tubule

  • ascending aorta

  • aortic valve

  • anterior horn of spinal cord

  • morula

  • cumulus cell

  • supraoptic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium channel activity
  • glycine binding
  • ion channel activity
  • ionotropic glutamate receptor activity
  • cation channel activity
  • neurotransmitter binding
  • neurotransmitter receptor activity
  • extracellularly glutamate-gated ion channel activity
  • signaling receptor activity
Cellular component
  • integral component of membrane
  • postsynaptic membrane
  • membrane
  • plasma membrane
  • synapse
  • cell junction
  • neuronal cell body
  • NMDA selective glutamate receptor complex
  • postsynapse
Biological process
  • regulation of calcium ion transport
  • ion transport
  • ionotropic glutamate receptor signaling pathway
  • protein insertion into membrane
  • calcium ion transmembrane transport
  • cation transmembrane transport
  • ion transmembrane transport
  • excitatory postsynaptic potential
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116444

170483

Ensembl

ENSG00000116032

ENSMUSG00000035745

UniProt

O60391
Q5F0I5

Q91ZU9

RefSeq (mRNA)

NM_138690

NM_130455

RefSeq (protein)

NP_619635
NP_619635.1

NP_569722

Location (UCSC)Chr 19: 1 – 1.01 MbChr 10: 79.81 – 79.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate [NMDA] receptor subunit 3B is a protein that in humans is encoded by the GRIN3B gene.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116032 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035745 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B".

Further reading

  • Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci...269.1737K. doi:10.1126/science.7569905. PMID 7569905.
  • Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237. S2CID 24405132.
  • Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977. S2CID 27201873.
  • Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036. S2CID 1669986.
  • Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". NeuroReport. 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048. S2CID 21018147.
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747. S2CID 32822686.
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372. S2CID 44260060.
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955. S2CID 7370984.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Raber J, Toggas SM, Lee S, et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.
  • New DR, Maggirwar SB, Epstein LG, et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389.
  • Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats". Neuroscience. 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID 10197777. S2CID 28927942.
  • Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428. S2CID 7598117.
  • Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system". AIDS Res. Hum. Retroviruses. 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.
  • Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID 11483648. S2CID 25641791.
  • Bonavia R, Bajetto A, Barbero S, et al. (2001). "HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons". Biochem. Biophys. Res. Commun. 288 (2): 301–8. doi:10.1006/bbrc.2001.5743. PMID 11606043.
  • Nishi M, Hinds H, Lu HP, et al. (2002). "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner". J. Neurosci. 21 (23): RC185. doi:10.1523/JNEUROSCI.21-23-j0003.2001. PMC 6763906. PMID 11717388.

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