GZMH

Protein-coding gene in the species Homo sapiens

GZMH

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3TJU, 3TJV, 3TK9, 4GAW

Identifiers

Aliases

GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, granzyme H

External IDs

OMIM: 116831; MGI: 109254; HomoloGene: 133275; GeneCards: GZMH; OMA:GZMH - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q12	Start	24,606,480 bp^[1]
Band	14q12	End	24,609,699 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 C3\|14 28.19 cM	Start	56,442,720 bp^[2]
Band	14 C3\|14 28.19 cM	End	56,448,874 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

blood

spleen

bone marrow cells

periodontal fiber

decidua

gallbladder

lymph node

right lung

palpebral conjunctiva

Top expressed in

gastrula

decidua

ankle joint

central gray substance of midbrain

nucleus of stria terminalis

uterus

yolk sac

tail of embryo

adipose tissue

dentate gyrus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity
Cellular component	membrane secretory granule cytoplasm
Biological process	cytolysis apoptotic process proteolysis granzyme-mediated apoptotic signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2999


14943

Ensembl


ENSG00000100450


ENSMUSG00000015441

UniProt


P20718


P08883

RefSeq (mRNA)


NM_001270780 NM_001270781 NM_033423


NM_010374

RefSeq (protein)


NP_001257709 NP_001257710 NP_219491


NP_034504

Location (UCSC)

Chr 14: 24.61 – 24.61 Mb

Chr 14: 56.44 – 56.45 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Granzyme H is a protein that in humans is encoded by the GZMH gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015441 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene" (PDF). Int Immunol. 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.
^ "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".

Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence". Nature. 274 (5671): 603–5. Bibcode:1978Natur.274..603L. doi:10.1038/274603a0. PMID 209336. S2CID 4293645.
Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2". J. Biol. Chem. 266 (10): 6152–8. doi:10.1016/S0021-9258(18)38097-9. PMID 2007574.
Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry. 29 (17): 4042–9. doi:10.1021/bi00469a003. PMID 2193684.
Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. Bibcode:1990PNAS...87..960H. doi:10.1073/pnas.87.3.960. PMC 53389. PMID 2300587.
Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens. 35 (5): 220–8. doi:10.1111/j.1399-0039.1990.tb01787.x. PMID 2402757.
MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood. 93 (3): 963–73. doi:10.1182/blood.V93.3.963. PMID 9920846.
Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes". J. Biol. Chem. 274 (43): 30468–73. doi:10.1074/jbc.274.43.30468. PMID 10521426.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C". Blood. 101 (8): 3093–101. doi:10.1182/blood-2002-08-2485. PMID 12515723.
Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes". J. Biol. Chem. 279 (25): 26581–7. doi:10.1074/jbc.M312481200. PMID 15069086.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMC 1852776. PMID 17363894.
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program". Blood. 110 (2): 544–52. doi:10.1182/blood-2006-10-051649. PMID 17409270.