IFNA5

Protein-coding gene in the species Homo sapiens
IFNA5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3OQ3

Identifiers
AliasesIFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G, interferon alpha 5
External IDsOMIM: 147565; MGI: 2667155; HomoloGene: 117697; GeneCards: IFNA5; OMA:IFNA5 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IFNA5
Genomic location for IFNA5
Band9p21.3Start21,304,326 bp[1]
End21,305,313 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for IFNA5
Genomic location for IFNA5
Band4 C4|4 42.02 cMStart88,561,878 bp[2]
End88,562,696 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • sural nerve

  • stromal cell of endometrium

  • right coronary artery

  • right lung

  • gastric mucosa

  • popliteal artery

  • islet of Langerhans

  • lymph node

  • lower lobe of lung
Top expressed in
  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cytokine activity
  • type I interferon receptor binding
  • cytokine receptor binding
Cellular component
  • extracellular region
  • extracellular space
Biological process
  • natural killer cell activation involved in immune response
  • B cell differentiation
  • defense response
  • B cell proliferation
  • blood coagulation
  • positive regulation of peptidyl-serine phosphorylation of STAT protein
  • humoral immune response
  • adaptive immune response
  • defense response to virus
  • type I interferon signaling pathway
  • response to exogenous dsRNA
  • T cell activation involved in immune response
  • innate immune response
  • cytokine-mediated signaling pathway
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3442

230396

Ensembl

ENSG00000147873

ENSMUSG00000063376

UniProt

P01569

Q80SU4

RefSeq (mRNA)

NM_002169

NM_177347

RefSeq (protein)

NP_002160

NP_796321

Location (UCSC)Chr 9: 21.3 – 21.31 MbChr 4: 88.56 – 88.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147873 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
  6. ^ "Entrez Gene: IFNA5 interferon, alpha 5".

Further reading

  • Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
  • Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
  • Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
  • Chuntharapai A, Gibbs V, Lu J, et al. (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. doi:10.4049/jimmunol.163.2.766. PMID 10395669.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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