IFT27

IFT27
Identifiers
Aliases	IFT27, BBS19, RABL4, RAYL, intraflagellar transport 27, FAP156
External IDs	OMIM: 615870; MGI: 1914292; HomoloGene: 4998; GeneCards: IFT27; OMA:IFT27 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 36,758,202 bp[1] End 36,776,256 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,043,663 bp[2] End 78,058,307 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube epithelium of bronchus bronchial epithelial cell olfactory zone of nasal mucosa anterior pituitary caudate nucleus nucleus accumbens C1 segment right lobe of thyroid gland right adrenal gland Top expressed in Rostral migratory stream internal carotid artery external carotid artery epithelium of lens medial ganglionic eminence Epithelium of choroid plexus facial motor nucleus condyle fossa maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity Cellular component cell projection motile cilium sperm principal piece sperm midpiece ciliary tip centrosome intraciliary transport particle B endosome Golgi apparatus cilium cytoplasm sperm flagellum membrane intracellular anatomical structure Biological process smoothened signaling pathway protein transport intracellular protein transport intraciliary transport cochlea development inner ear receptor cell stereocilium organization intraciliary transport involved in cilium assembly kidney development spermatogenesis Rab protein signal transduction cell differentiation signal transduction small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11020 67042 Ensembl ENSG00000100360 ENSMUSG00000016637 UniProt Q9BW83 Q9D0P8 RefSeq (mRNA) NM_001177701 NM_001177702 NM_006860 NM_001363003 NM_025931 RefSeq (protein) NP_001171172 NP_006851 NP_001349932 NP_080207 Location (UCSC) Chr 22: 36.76 – 36.78 Mb Chr 15: 78.04 – 78.06 Mb PubMed search [3] [4]
Wikidata
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Intraflagellar transport 27 is a protein that in humans is encoded by the IFT27 gene. ^[5]

Function

This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.