IFT74

Protein-coding gene in the species Homo sapiens
IFT74
Identifiers
AliasesIFT74, CCDC2, CMG-1, CMG1, intraflagellar transport 74, BBS20, BBS22, SPGF58, JBTS40
External IDsOMIM: 608040; MGI: 1914944; HomoloGene: 11831; GeneCards: IFT74; OMA:IFT74 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IFT74
Genomic location for IFT74
Band9p21.2Start26,947,039 bp[1]
End27,066,134 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for IFT74
Genomic location for IFT74
Band4|4 C5Start94,614,491 bp[2]
End94,693,229 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • caput epididymis

  • right uterine tube

  • Achilles tendon

  • corpus epididymis

  • left testis

  • right testis

  • testicle

  • gonad

  • mucosa of paranasal sinus
Top expressed in
  • seminiferous tubule

  • olfactory epithelium

  • spermatid

  • spermatocyte

  • maxillary prominence

  • mandibular prominence

  • saccule

  • Gonadal ridge

  • otic vesicle

  • Epithelium of choroid plexus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • chromatin binding
  • beta-tubulin binding
  • protein binding
Cellular component
  • intraciliary transport particle B
  • centrosome
  • cell projection
  • ciliary tip
  • motile cilium
  • cytoplasmic vesicle
  • nucleus
  • cilium
Biological process
  • Notch signaling pathway
  • intraciliary transport
  • heart development
  • keratinocyte development
  • determination of left/right symmetry
  • cell projection organization
  • epidermis development
  • negative regulation of epithelial cell proliferation
  • positive regulation of cell adhesion mediated by integrin
  • positive regulation of transcription by RNA polymerase II
  • intraciliary transport involved in cilium assembly
  • cilium assembly
  • non-motile cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80173

67694

Ensembl

ENSG00000096872

ENSMUSG00000028576

UniProt

Q96LB3

Q8BKE9

RefSeq (mRNA)

NM_001099222
NM_001099223
NM_001099224
NM_025103
NM_001349928

NM_001290568
NM_026319

RefSeq (protein)

NP_001092692
NP_001092693
NP_001092694
NP_079379
NP_001336857

NP_001277497
NP_080595

Location (UCSC)Chr 9: 26.95 – 27.07 MbChr 4: 94.61 – 94.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.[5][6]

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096872 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028576 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
  6. ^ a b Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID 11683410.

Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID 17383054. S2CID 10392826.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


  • v
  • t
  • e