KIAA0409

Protein-coding gene in the species Homo sapiens
RRP8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ZFU

Identifiers
AliasesRRP8, KIAA0409, NML, ribosomal RNA processing 8, methyltransferase, homolog (yeast), ribosomal RNA processing 8
External IDsOMIM: 615818; MGI: 1914251; HomoloGene: 5621; GeneCards: RRP8; OMA:RRP8 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RRP8
Genomic location for RRP8
Band11p15.4Start6,595,072 bp[1]
End6,603,616 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RRP8
Genomic location for RRP8
Band7|7 E3Start105,380,937 bp[2]
End105,386,592 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle layer of sigmoid colon

  • right lobe of liver

  • gonad

  • mucosa of transverse colon

  • popliteal artery

  • tibial arteries

  • ventricular zone

  • granulocyte

  • body of uterus

  • right auricle
Top expressed in
  • zygote

  • genital tubercle

  • tail of embryo

  • primitive streak

  • epiblast

  • ureter

  • embryo

  • primary oocyte

  • embryo

  • secondary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • methylated histone binding
  • protein binding
  • RNA binding
Cellular component
  • plasma membrane
  • nucleoplasm
  • rDNA heterochromatin
  • chromatin silencing complex
  • nucleolus
  • nucleus
  • cytosol
Biological process
  • cellular response to glucose starvation
  • regulation of transcription, DNA-templated
  • regulation of transcription by glucose
  • transcription, DNA-templated
  • methylation
  • rDNA heterochromatin assembly
  • intrinsic apoptotic signaling pathway by p53 class mediator
  • rRNA processing
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23378

101867

Ensembl

ENSG00000132275

ENSMUSG00000030888

UniProt

O43159

Q9DB85

RefSeq (mRNA)

NM_015324

NM_025897
NM_133951

RefSeq (protein)

NP_056139

NP_080173
NP_598712

Location (UCSC)Chr 11: 6.6 – 6.6 MbChr 7: 105.38 – 105.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132275 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030888 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ "Entrez Gene: KIAA0409 KIAA0409".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribosomal RNA-processing protein 8 (KIAA0409)



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