LUC7L

Protein-coding gene in humans
LUC7L
Identifiers
AliasesLUC7L, LUC7-LIKE, LUC7B1, Luc7, SR+89, hLuc7B1, LUC7 like
External IDsOMIM: 607782; MGI: 1914228; HomoloGene: 100558; GeneCards: LUC7L; OMA:LUC7L - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for LUC7L
Genomic location for LUC7L
Band16p13.3Start188,969 bp[1]
End229,463 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for LUC7L
Genomic location for LUC7L
Band17 A3.3|17 13.09 cMStart26,471,870 bp[2]
End26,504,478 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • sural nerve

  • anterior pituitary

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • right uterine tube

  • canal of the cervix

  • body of uterus
Top expressed in
  • neural layer of retina

  • Rostral migratory stream

  • abdominal wall

  • ventricular zone

  • medullary collecting duct

  • epiblast

  • morula

  • facial motor nucleus

  • ventromedial nucleus

  • substantia nigra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RS domain binding
  • protein binding
  • mRNA binding
  • identical protein binding
Cellular component
  • U1 snRNP
  • U2-type prespliceosome
  • nucleus
Biological process
  • mRNA splice site selection
  • negative regulation of striated muscle tissue development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55692

66978

Ensembl

ENSG00000007392

ENSMUSG00000024188

UniProt

Q9NQ29
Q1W6G4

Q9CYI4

RefSeq (mRNA)

NM_018032
NM_201412
NM_001320226
NM_001330420

NM_025881
NM_028190

RefSeq (protein)
NP_001307155
NP_001317349
NP_060502
NP_958815
NP_060502.1

NP_001307155.1

NP_080157
NP_082466

Location (UCSC)Chr 16: 0.19 – 0.23 MbChr 17: 26.47 – 26.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene.[5]

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007392 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024188 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LUC7L LUC7-like (S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • Tufarelli C, Frischauf AM, Hardison R, et al. (2001). "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID 11170747.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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