NEO1

Protein-coding gene in the species Homo sapiens

NEO1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2

Identifiers

Aliases

NEO1, IGDCC2, NGN, NTN1R2, neogenin 1

External IDs

OMIM: 601907; MGI: 1097159; HomoloGene: 1870; GeneCards: NEO1; OMA:NEO1 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q24.1	Start	73,051,710 bp^[1]
Band	15q24.1	End	73,305,205 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 B	Start	58,781,970 bp^[2]
Band	9\|9 B	End	58,943,724 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

internal globus pallidus

inferior ganglion of vagus nerve

rectum

epithelium of colon

subthalamic nucleus

corpus callosum

ventral tegmental area

superior vestibular nucleus

pylorus

Top expressed in

external carotid artery

internal carotid artery

epithelium of lens

renal corpuscle

medullary collecting duct

substantia nigra

ciliary body

ascending aorta

Rostral migratory stream

aortic valve

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	co-receptor binding protein binding signaling receptor activity
Cellular component	integral component of membrane plasma membrane protein complex plasma membrane Golgi apparatus integral component of plasma membrane membrane nucleoplasm
Biological process	positive regulation of BMP signaling pathway iron ion homeostasis cell adhesion nervous system development axon guidance signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4756


18007

Ensembl


ENSG00000067141


ENSMUSG00000032340

UniProt


Q92859


P97798

RefSeq (mRNA)


NM_001172623 NM_001172624 NM_002499


NM_001042752 NM_008684

RefSeq (protein)


NP_001166094 NP_001166095 NP_002490


n/a

Location (UCSC)

Chr 15: 73.05 – 73.31 Mb

Chr 9: 58.78 – 58.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[5]^[6]

Interactions

NEO1 has been shown to interact with PTK2.^[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. ^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032340 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
^ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
^ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
^ Do Carmo Costa, Alinne; Copola, Aline Gonçalves Lio; Carvalho e Souza, Clara; Nogueira, Júlia Meireles; Silva, Gerluza Aparecida Borges; Jorge, Erika Cristina (2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology - Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578.
Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors". J. Neurosci. 19 (12): 4938–47. doi:10.1523/JNEUROSCI.19-12-04938.1999. PMC 6782680. PMID 10366627.
Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell. 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591. S2CID 15433313.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer". BMC Cancer. 5: 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

PDB gallery

1x5f: The solution structure of the first fibronectin type III domain of human Neogenin
1x5g: The solution structure of the second fibronectin type III domain of human Neogenin
1x5h: The solution structure of the third fibronectin type III domain of human Neogenin
1x5i: The solution structure of the fourth fibronectin type III domain of human Neogenin
1x5j: The solution structure of the fifth fibronectin type III domain of human Neogenin
1x5k: The solution structure of the sixth fibronectin type III domain of human Neogenin