Nucleolar and spindle associated protein 1

Protein-coding gene in the species Homo sapiens
NUSAP1
Identifiers
AliasesNUSAP1, ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL, nucleolar and spindle associated protein 1
External IDsOMIM: 612818; MGI: 2675669; HomoloGene: 10207; GeneCards: NUSAP1; OMA:NUSAP1 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for NUSAP1
Genomic location for NUSAP1
Band15q15.1Start41,320,794 bp[1]
End41,381,050 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for NUSAP1
Genomic location for NUSAP1
Band2|2 E5Start119,448,779 bp[2]
End119,481,725 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • bone marrow

  • bone marrow cells

  • appendix

  • lymph node

  • stromal cell of endometrium

  • rectum

  • placenta

  • duodenum

  • testicle
Top expressed in
  • medial ganglionic eminence

  • blood

  • dermis

  • thymus

  • otic placode

  • ureter

  • abdominal wall

  • hand

  • secondary oocyte

  • atrioventricular valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • DNA binding
  • protein binding
  • RNA binding
Cellular component
  • spindle
  • spindle microtubule
  • cytoskeleton
  • microtubule
  • chromosome
  • nucleus
  • nucleolus
  • cytoplasm
  • mitotic spindle
Biological process
  • cell division
  • cell cycle
  • mitotic cytokinesis
  • mitotic chromosome condensation
  • establishment of mitotic spindle localization
  • positive regulation of mitotic nuclear division
  • microtubule cytoskeleton organization
  • mitotic sister chromatid segregation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51203

108907

Ensembl

ENSG00000137804

ENSMUSG00000027306

UniProt

Q9BXS6

Q9ERH4

RefSeq (mRNA)
NM_001129897
NM_001243142
NM_001243143
NM_001243144
NM_001301136

NM_016359
NM_018454

NM_001042652
NM_133851

RefSeq (protein)
NP_001230071
NP_001230072
NP_001230073
NP_001288065
NP_057443

NP_060924

NP_001036117
NP_598612

Location (UCSC)Chr 15: 41.32 – 41.38 MbChr 2: 119.45 – 119.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar and spindle associated protein 1 is a protein that in humans is encoded by the NUSAP1 gene. [5]

Function

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137804 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027306 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Nucleolar and spindle associated protein 1". Retrieved 2018-05-22.

Further reading

  • Wadia PP, Coram M, Armstrong RJ, Mindrinos M, Butte AJ, Miklos DB (March 2010). "Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation". Blood. 115 (10): 2077–87. doi:10.1182/blood-2009-03-211375. PMC 2837325. PMID 20053754.
  • Verbakel W, Carmeliet G, Engelborghs Y (August 2011). "SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction". Biochem. Biophys. Res. Commun. 411 (4): 732–7. doi:10.1016/j.bbrc.2011.07.015. PMID 21782797.
  • Chou HY, Wang TH, Lee SC, Hsu PH, Tsai MD, Chang CL, Jeng YM (December 2011). "Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis". Cell Cycle. 10 (23): 4083–9. doi:10.4161/cc.10.23.18200. PMID 22101338.
  • Gulzar ZG, McKenney JK, Brooks JD (January 2013). "Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1". Oncogene. 32 (1): 70–7. doi:10.1038/onc.2012.27. PMC 3360134. PMID 22349817.
  • Espinosa AM, Alfaro A, Roman-Basaure E, Guardado-Estrada M, Palma Í, Serralde C, Medina I, Juárez E, Bermúdez M, Márquez E, Borges-Ibáñez M, Muñoz-Cortez S, Alcántara-Vázquez A, Alonso P, Curiel-Valdez J, Kofman S, Villegas N, Berumen J (2013). "Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer". PLOS ONE. 8 (2): e55975. Bibcode:2013PLoSO...855975E. doi:10.1371/journal.pone.0055975. PMC 3566100. PMID 23405241.
  • Kotian S, Banerjee T, Lockhart A, Huang K, Catalyurek UV, Parvin JD (May 2014). "NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels". Cancer Biol. Ther. 15 (5): 533–43. doi:10.4161/cbt.28019. PMC 4026076. PMID 24521615.
  • Chen L, Yang L, Qiao F, Hu X, Li S, Yao L, Yang XL, Shao ZM (2015). "High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer". PLOS ONE. 10 (10): e0140572. Bibcode:2015PLoSO..1040572C. doi:10.1371/journal.pone.0140572. PMC 4618922. PMID 26485712.
  • Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, Tanzawa H, Uzawa K (2015). "Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma". PLOS ONE. 10 (11): e0142252. Bibcode:2015PLoSO..1042252O. doi:10.1371/journal.pone.0142252. PMC 4640814. PMID 26554377.
  • Li C, Zhang Y, Yang Q, Ye F, Sun SY, Chen ES, Liou YC (January 2016). "NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity". Sci Rep. 6: 18773. Bibcode:2016NatSR...618773L. doi:10.1038/srep18773. PMC 4702128. PMID 26733216.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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