OR2AG1

Protein-coding gene in the species Homo sapiens
OR2AG1
Identifiers
AliasesOR2AG1, OR11-79, OR2AG3, olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene), olfactory receptor family 2 subfamily AG member 1
External IDsMGI: 3030539; HomoloGene: 128075; GeneCards: OR2AG1; OMA:OR2AG1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR2AG1
Genomic location for OR2AG1
Band11p15.4Start6,783,020 bp[1]
End6,791,558 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR2AG1
Genomic location for OR2AG1
Band7|7 E3Start106,471,077 bp[2]
End106,476,098 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • sural nerve

  • superior frontal gyrus

  • prefrontal cortex

  • temporal lobe

  • amygdala
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • olfactory receptor activity
  • G protein-coupled receptor activity
  • protein binding
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

144125

259034

Ensembl

ENSG00000279486

ENSMUSG00000109058

UniProt

Q9H205

Q9EPF7

RefSeq (mRNA)

NM_001004489

NM_147032

RefSeq (protein)

NP_001004489

NP_667243

Location (UCSC)Chr 11: 6.78 – 6.79 MbChr 7: 106.47 – 106.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

Amyl butyrate is a reported ligand for this receptor. [6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000279486 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000109058 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1".
  6. ^ Shepard BD, Pluznick JL (May 2016). "How does your kidney smell? Emerging roles for olfactory receptors in renal function". Pediatric Nephrology (Berlin, Germany). 31 (5): 715–23. doi:10.1007/s00467-015-3181-8. PMC 4752438. PMID 26264790.

Further reading

  • Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi:10.1073/pnas.131215398. PMC 34679. PMID 11416212.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  • Neuhaus EM, Mashukova A, Zhang W, et al. (2006). "A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins". Chem. Senses. 31 (5): 445–52. doi:10.1093/chemse/bjj049. PMID 16565291.
  • Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006). "Beta-arrestin2-mediated internalization of mammalian odorant receptors". J. Neurosci. 26 (39): 9902–12. doi:10.1523/JNEUROSCI.2897-06.2006. PMC 6674477. PMID 17005854.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
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Family 3
Family 4
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Family 10
Family 11
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Family 13


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