Ozolinone
Chemical compound
- None
- In general: uncontrolled
- (2Z)-2-(3-methyl-4-oxo-5-piperidin-1-yl-1,3-thiazolidin-2-ylidene)acetic acid
- 56784-39-5
- 6436036
- 23253355
- 55TIT7J81D
- D05323
- DTXSID30866590
- Interactive image
- O=C(O)/C=C1/N(C)C(=O)C(S1)N2CCCCC2
Ozolinone is a loop diuretic which was never marketed.[1][2][3]
It is an active metabolite of etozoline.[2]
See also
- Etozoline — a prodrug of ozolinone
References
- ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- ^ a b Greven J, Heidenreich O (October 1978). "Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function. I. Clearance studies in dogs". Naunyn-Schmiedeberg's Archives of Pharmacology. 304 (3): 283–7. doi:10.1007/bf00507970. PMID 714186. S2CID 20878253.
- ^ Greven J, Beckers M, Defrain W, Meywald K, Heidenreich O (March 1980). "Studies with the optically active isomers of the new diuretic drug ozolinone. II. Inhibition by d-ozolinone of furosemide-induced diuresis". Pflügers Archiv: European Journal of Physiology. 384 (1): 61–4. doi:10.1007/bf00589515. PMID 7189867. S2CID 13461213.
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Diuretics (C03)
(and etacrynic acid)
| CA inhibitors (at PT) | |
|---|---|
| Loop (Na-K-Cl at AL) | |
| Thiazides (Na-Cl at DCT, Calcium-sparing) | |
| Thiazide-likes (primarily DCT) |
| ESC blockers | |
|---|---|
| Aldosterone antagonists |
(DCT and CD)
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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