PCGF6

Protein-coding gene in the species Homo sapiens
PCGF6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DJB

Identifiers
AliasesPCGF6, MBLR, RNF134, polycomb group ring finger 6
External IDsOMIM: 607816; MGI: 1918291; HomoloGene: 12378; GeneCards: PCGF6; OMA:PCGF6 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PCGF6
Genomic location for PCGF6
Band10q24.33Start103,302,796 bp[1]
End103,351,144 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for PCGF6
Genomic location for PCGF6
Band19|19 C3Start47,022,056 bp[2]
End47,039,345 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • ventricular zone

  • gastrocnemius muscle

  • testicle

  • skeletal muscle tissue

  • stromal cell of endometrium

  • smooth muscle tissue

  • ganglionic eminence

  • tibial arteries

  • muscle layer of sigmoid colon
Top expressed in
  • zygote

  • spermatocyte

  • primary oocyte

  • secondary oocyte

  • epiblast

  • seminiferous tubule

  • primitive streak

  • Rostral migratory stream

  • embryo

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • protein binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • metal ion binding
Cellular component
  • nucleus
  • PcG protein complex
  • nucleoplasm
  • PRC1 complex
Biological process
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • histone H2A-K119 monoubiquitination
  • negative regulation of G0 to G1 transition
  • negative regulation of transcription, DNA-templated
  • inactivation of X chromosome by genetic imprinting
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84108

71041

Ensembl

ENSG00000156374

ENSMUSG00000025050

UniProt

Q9BYE7

Q99NA9

RefSeq (mRNA)

NM_001011663
NM_032154

NM_027654
NM_001360632

RefSeq (protein)

NP_001011663
NP_115530

NP_081930
NP_001347561

Location (UCSC)Chr 10: 103.3 – 103.35 MbChr 19: 47.02 – 47.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.[5][6]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156374 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025050 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. hdl:2027.42/72663. PMID 12167161. S2CID 23060582.
  6. ^ a b "Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading

  • Kanno M, Hasegawa M, Ishida A, et al. (1996). "mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity". EMBO J. 14 (22): 5672–8. doi:10.1002/j.1460-2075.1995.tb00254.x. PMC 394682. PMID 8521824.
  • Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
  • Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. doi:10.1242/dev.129.18.4171. PMID 12183370.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. Biophys. Res. Commun. 338 (2): 855–61. doi:10.1016/j.bbrc.2005.10.020. PMID 16248985.
  • Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein". Cell. 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162. S2CID 6519228.
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  • 2djb: Solution structure of the RING domain of the human Polycomb group RING finger protein 6
    2djb: Solution structure of the RING domain of the human Polycomb group RING finger protein 6


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