Phospholipase A2 group IVD

Protein-coding gene in the species Homo sapiens
PLA2G4D
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IXC, 5IZR, 5IZ5

Identifiers
AliasesPLA2G4D, cPLA2delta, phospholipase A2 group IVD
External IDsOMIM: 612864; MGI: 1925640; HomoloGene: 52252; GeneCards: PLA2G4D; OMA:PLA2G4D - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for PLA2G4D
Genomic location for PLA2G4D
Band15q15.1Start42,067,009 bp[1]
End42,094,562 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PLA2G4D
Genomic location for PLA2G4D
Band2|2 E5Start120,096,076 bp[2]
End120,119,678 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • vagina

  • pituitary gland

  • anterior pituitary

  • prostate

  • endometrium

  • mucosa of large intestine

  • left adrenal gland

  • hippocampus proper

  • duodenum
Top expressed in
  • esophagus

  • placenta

  • secondary oocyte

  • spermatid

  • seminiferous tubule

  • lip

  • medial ganglionic eminence

  • spermatocyte

  • vastus lateralis muscle

  • temporal muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phospholipase activity
  • metal ion binding
  • hydrolase activity
  • phospholipase A1 activity
  • lysophospholipase activity
  • phospholipase A2 activity
  • calcium-dependent phospholipase A2 activity
  • calcium ion binding
  • calcium-dependent phospholipid binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
Biological process
  • phosphatidic acid biosynthetic process
  • phosphatidylserine acyl-chain remodeling
  • phosphatidylethanolamine acyl-chain remodeling
  • lipid metabolism
  • phosphatidylinositol acyl-chain remodeling
  • lipid catabolic process
  • phosphatidylglycerol acyl-chain remodeling
  • phospholipid catabolic process
  • phospholipid metabolic process
  • metabolism
  • phosphatidylcholine acyl-chain remodeling
  • glycerophospholipid catabolic process
  • fatty acid metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283748

78390

Ensembl

ENSG00000159337

ENSMUSG00000070719

UniProt

Q86XP0

Q50L43

RefSeq (mRNA)

NM_178034

NM_001024137

RefSeq (protein)

NP_828848

NP_001019308

Location (UCSC)Chr 15: 42.07 – 42.09 MbChr 2: 120.1 – 120.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. [5]

Function

The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159337 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070719 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Phospholipase A2 group IVD". Retrieved 2017-09-13.
  6. ^ Chiba, H; Michibata, H; Wakimoto, K; Seishima, M; Kawasaki, S; Okubo, K; Mitsui, H; Torii, H; Imai, Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". Journal of Biological Chemistry. 279 (13): 12890–7. doi:10.1074/jbc.M305801200. PMID 14709560.

Further reading

  • Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". J. Biol. Chem. 279 (13): 12890–7. doi:10.1074/jbc.M305801200. PMID 14709560.
  • Tao R, Yu Y, Zhang X, Shi J, Guo Y, Wang C, Han B, Xu Q, Shang H, Zhang X, Xie L, Liu S, Ju G, Shen Y, Wei J (2005). "A family based study of the genetic association between the PLA2G4D gene and schizophrenia". Prostaglandins Leukot. Essent. Fatty Acids. 73 (6): 419–22. doi:10.1016/j.plefa.2005.08.008. PMID 16213696.
  • Yu Q, Shi JP, Kou CG, Meng XF, Yu YQ (2008). "[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]". Zhonghua Liu Xing Bing Xue Za Zhi (in Chinese). 29 (2): 173–6. PMID 18686860.
  • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
  • Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
  • Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC (2013). "Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma". PLOS ONE. 8 (12): e83244. Bibcode:2013PLoSO...883244P. doi:10.1371/journal.pone.0083244. PMC 3862727. PMID 24349473.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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