RTN2

Protein-coding gene in the species Homo sapiens
RTN2
Identifiers
AliasesRTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDsOMIM: 603183; MGI: 107612; HomoloGene: 32180; GeneCards: RTN2; OMA:RTN2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RTN2
Genomic location for RTN2
Band19q13.32Start45,485,294 bp[1]
End45,497,055 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RTN2
Genomic location for RTN2
Band7 A3|7 9.54 cMStart19,016,549 bp[2]
End19,030,085 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Skeletal muscle tissue of rectus abdominis

  • muscle of thigh

  • gastrocnemius muscle

  • vastus lateralis muscle

  • thoracic diaphragm

  • triceps brachii muscle

  • biceps brachii

  • glutes

  • body of tongue

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • triceps brachii muscle

  • muscle of thigh

  • temporal muscle

  • sternocleidomastoid muscle

  • ankle

  • digastric muscle

  • extensor digitorum longus muscle

  • vastus lateralis muscle

  • medial head of gastrocnemius muscle

  • tibialis anterior muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • T-tubule
  • integral component of endoplasmic reticulum membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • terminal cisterna
Biological process
  • intracellular protein transmembrane transport
  • regulation of glucose import
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6253

20167

Ensembl

ENSG00000125744

ENSMUSG00000030401

UniProt

O75298
Q96CG9

O70622

RefSeq (mRNA)

NM_206902
NM_005619
NM_206900
NM_206901

NM_001025364
NM_013648

RefSeq (protein)

NP_005610
NP_996783
NP_996784

NP_001020535
NP_038676

Location (UCSC)Chr 19: 45.49 – 45.5 MbChr 7: 19.02 – 19.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.[5][6][7]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125744 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030401 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.
  6. ^ Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. S2CID 7091637.
  7. ^ a b "Entrez Gene: RTN2 reticulon 2".

Further reading

  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784. S2CID 23570406.
  • Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
  • Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288. S2CID 27903.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein". J. Muscle Res. Cell. Motil. 20 (7): 661–8. doi:10.1023/A:1005533013926. PMID 10672514. S2CID 26327921.
  • Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons". Genomics. 51 (1): 98–106. doi:10.1006/geno.1997.5175. PMID 9693037.


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