Raseglurant
Chemical compound
- None
- 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine
- 757950-09-7
- 10331863
- 8507323
- 66UCJ8Z8L1
- DTXSID40226707
- Interactive image
- Fc2cccc(C#Cc1nc(cc(c1N)C)C)c2
InChI
- InChI=1S/C15H13FN2/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12/h3-5,8-9H,17H2,1-2H3
- Key:MEDCLNYIYBERKO-UHFFFAOYSA-N
Raseglurant (INN) (code name ADX-10059) is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety.[1][2][3] It reached phase II clinical trials for all of the aforementioned indications before being discontinued due to the observation of possible predictive signs of hepatotoxicity in patients with long-term use.[3][4][5]
See also
References
- ^ Célanire S, Duvey G, Poli S, Rocher JP (January 2012). "mGluR2 activators and mGluR5 blockers advancing in the clinic for major CNS disorders.". Annual Reports in Medicinal Chemistry. Vol. 47. Academic Press. pp. 71–88. ISBN 978-0-12-397214-9.
- ^ "Don't Dodge the Dentist – Tips for Dealing with Dental Anxiety". Retrieved 2017-04-05.
- ^ a b Stein MB, Steckler T (30 July 2010). Behavioral Neurobiology of Anxiety and Its Treatment. Springer Science & Business Media. pp. 397–. ISBN 978-3-642-02912-7.
- ^ Dominguez C (18 November 2010). Neurodegenerative Diseases. Springer Science & Business Media. pp. 120–. ISBN 978-3-642-16758-4.
- ^ Shaheen NJ (25 March 2013). Benign and Neoplastic Conditions of the Esophagus, An Issue of Gastroenterology Clinics. Elsevier Health Sciences. pp. 119–. ISBN 978-1-4557-7175-2.
External links
- Development of ADX10059 Ended for Long-term Use - Addex Therapeutics
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mGluR1Tooltip Metabotropic glutamate receptor 1 |
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mGluR5Tooltip Metabotropic glutamate receptor 5 |
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mGluR2Tooltip Metabotropic glutamate receptor 2 |
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mGluR3Tooltip Metabotropic glutamate receptor 3 |
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mGluR4Tooltip Metabotropic glutamate receptor 4 |
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mGluR6Tooltip Metabotropic glutamate receptor 6 |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
mGluR8Tooltip Metabotropic glutamate receptor 8 |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
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