SART1

Protein-coding gene in the species Homo sapiens

SART1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4PYU

Identifiers

Aliases

SART1, Ara1, HOMS1, SART1259, SNRNP110, Snu66, squamous cell carcinoma antigen recognized by T-cells 1, HAF, U4/U6.U5 tri-snRNP-associated protein 1, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

External IDs

OMIM: 605941; MGI: 1309453; HomoloGene: 133770; GeneCards: SART1; OMA:SART1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.1	Start	65,961,728 bp^[1]
Band	11q13.1	End	65,980,137 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	5,427,551 bp^[2]
Band	19\|19 A	End	5,438,731 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

apex of heart

granulocyte

olfactory zone of nasal mucosa

ectocervix

mucosa of transverse colon

anterior pituitary

canal of the cervix

right lobe of thyroid gland

skin of leg

Top expressed in

neural layer of retina

ventricular zone

yolk sac

granulocyte

saccule

otic placode

thymus

otic vesicle

epiblast

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding RNA binding
Cellular component	cytoplasm cytosol Cajal body Golgi apparatus U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome spliceosomal complex nucleus nucleoplasm nuclear speck U2-type precatalytic spliceosome
Biological process	mRNA cis splicing, via spliceosome positive regulation of cytotoxic T cell differentiation intrinsic apoptotic signaling pathway mRNA splicing, via spliceosome mRNA processing maturation of 5S rRNA spliceosomal snRNP assembly RNA splicing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9092


20227

Ensembl


ENSG00000175467


ENSMUSG00000039148

UniProt


O43290


Q9Z315

RefSeq (mRNA)


NM_005146


NM_016882

RefSeq (protein)


NP_005137


NP_058578

Location (UCSC)

Chr 11: 65.96 – 65.98 Mb

Chr 19: 5.43 – 5.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene.^[5]^[6] This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175467 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K (Mar 1998). "A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes". J Exp Med. 187 (3): 277–88. doi:10.1084/jem.187.3.277. PMC 2212124. PMID 9449708.
^ ^a ^b "Entrez Gene: SART1 squamous cell carcinoma antigen recognized by T cells".

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Matsunaga K, Nakao M, Masuoka K, et al. (1999). "Cytokines required for induction of histocompatibility leukocyte antigen-class I-restricted and tumor-specific cytotoxic T lymphocytes by a SART1-derived peptide". Jpn. J. Cancer Res. 90 (9): 1007–15. doi:10.1111/j.1349-7006.1999.tb00849.x. PMC 5926162. PMID 10551332.
Ishida H, Komiya S, Inoue Y, et al. (2000). "Expression of the SART1 tumor-rejection antigen in human osteosarcomas". Int. J. Oncol. 17 (1): 29–32. doi:10.3892/ijo.17.1.29. PMID 10853014.
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Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–63. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
Bolland DJ, Hewitt JE (2001). "Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis". Gene. 271 (1): 43–9. doi:10.1016/S0378-1119(01)00504-2. PMID 11410364.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Bell M, Schreiner S, Damianov A, et al. (2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". EMBO J. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMC 126028. PMID 12032085.
Wheatley AP, Bolland DJ, Hewitt JE, et al. (2003). "Identification of the autoantigen SART-1 as a candidate gene for the development of atopy". Hum. Mol. Genet. 11 (18): 2143–6. doi:10.1093/hmg/11.18.2143. PMID 12189166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.