SCYL2

Protein-coding gene in humans
SCYL2
Identifiers
AliasesSCYL2, CVAK104, SCY1 like pseudokinase 2, AMCNACC, AMC4
External IDsOMIM: 616365; MGI: 1289172; HomoloGene: 13349; GeneCards: SCYL2; OMA:SCYL2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SCYL2
Genomic location for SCYL2
Band12q23.1Start100,267,140 bp[1]
End100,341,715 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SCYL2
Genomic location for SCYL2
Band10 C2|10 45.05 cMStart89,474,583 bp[2]
End89,522,147 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of sigmoid colon

  • corpus epididymis

  • secondary oocyte

  • jejunal mucosa

  • palpebral conjunctiva

  • amniotic fluid

  • oral cavity

  • rectum

  • tail of epididymis

  • monocyte
Top expressed in
  • secondary oocyte

  • zygote

  • hand

  • primary oocyte

  • lumbar spinal ganglion

  • tail of embryo

  • superior cervical ganglion

  • granulocyte

  • genital tubercle

  • endocardial cushion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ATP binding
  • signaling receptor binding
  • protein kinase activity
  • protein binding
Cellular component
  • Golgi apparatus
  • endosome membrane
  • membrane
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • cytoplasm
  • endosome
  • perinuclear region of cytoplasm
Biological process
  • receptor internalization involved in canonical Wnt signaling pathway
  • negative regulation of canonical Wnt signaling pathway
  • protein phosphorylation
  • endosome to lysosome transport
  • positive regulation of clathrin-dependent endocytosis
  • positive regulation of receptor internalization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55681

213326

Ensembl

ENSG00000136021

ENSMUSG00000069539

UniProt

Q6P3W7

Q8CFE4

RefSeq (mRNA)

NM_017988
NM_001317784
NM_001330253
NM_001330254
NM_001330256

NM_198021
NM_001310704
NM_001358843

RefSeq (protein)

NP_001304713
NP_001317182
NP_001317183
NP_001317185
NP_060458

NP_001297633
NP_932138
NP_001345772

Location (UCSC)Chr 12: 100.27 – 100.34 MbChr 10: 89.47 – 89.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136021 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069539 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  6. ^ "Entrez Gene: SCYL2 SCY1-like 2 (S. cerevisiae)".

Further reading

  • Borner GH, Rana AA, Forster R, et al. (2007). "CVAK104 is a Novel Regulator of Clathrin-mediated SNARE Sorting". Traffic. 8 (7): 893–903. doi:10.1111/j.1600-0854.2007.00576.x. PMC 2239300. PMID 17587408.
  • Düwel M, Ungewickell EJ (2007). "Clathrin-dependent Association of CVAK104 with Endosomes and the Trans-Golgi Network". Mol. Biol. Cell. 17 (10): 4513–25. doi:10.1091/mbc.E06-05-0390. PMC 1635376. PMID 16914521.
  • Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLOS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.
  • Conner SD, Schmid SL (2005). "CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2". J. Biol. Chem. 280 (22): 21539–44. doi:10.1074/jbc.M502462200. PMID 15809293.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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