SLFN11

Protein-coding gene in the species Homo sapiens
SLFN11
Identifiers
AliasesSLFN11, SLFN8/9, schlafen family member 11
External IDsOMIM: 614953; MGI: 2672859; HomoloGene: 89175; GeneCards: SLFN11; OMA:SLFN11 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SLFN11
Genomic location for SLFN11
Band17q12Start35,350,305 bp[1]
End35,373,701 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SLFN11
Genomic location for SLFN11
Band11|11 CStart82,892,984 bp[2]
End82,911,636 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • Achilles tendon

  • sural nerve

  • bone marrow cells

  • right lobe of thyroid gland

  • left uterine tube

  • left lobe of thyroid gland

  • granulocyte

  • appendix

  • upper lobe of left lung
Top expressed in
  • spleen

  • granulocyte

  • thymus

  • bone marrow

  • embryo

  • ovary

  • embryo

  • zone of skin

  • jejunum

  • liver
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • tRNA binding
  • nucleotide binding
  • ATP binding
  • RNA binding
  • protein binding
  • ATPase activity
  • helicase activity
  • hydrolase activity
Cellular component
  • aggresome
  • nucleus
  • nucleoplasm
  • cytosol
  • site of DNA damage
  • chromosome
Biological process
  • negative regulation of G1/S transition of mitotic cell cycle
  • defense response to virus
  • immune system process
  • negative regulation of DNA replication
  • positive regulation of cell death
  • replication fork arrest
  • cellular response to DNA damage stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

91607

276950

Ensembl

ENSG00000172716

ENSMUSG00000035208

UniProt

Q7Z7L1

B1ARD8

RefSeq (mRNA)
NM_001104587
NM_001104588
NM_001104589
NM_001104590
NM_152270

NM_001376007
NM_001376008
NM_001376009
NM_001376010
NM_001376011
NM_001376012
NM_001387158
NM_001387159
NM_001387160
NM_001387161
NM_001387162
NM_001387163

NM_001167743
NM_181545

RefSeq (protein)
NP_001098057
NP_001098058
NP_001098059
NP_001098060
NP_689483

NP_001362936
NP_001362937
NP_001362938
NP_001362939
NP_001362940
NP_001362941

NP_001161215
NP_853523

Location (UCSC)Chr 17: 35.35 – 35.37 MbChr 11: 82.89 – 82.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035208 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: SLFN11 schlafen family member 11".

Further reading

  • Schwarz DA, Katayama CD, Hedrick SM (1998). "Schlafen, a new family of growth regulatory genes that affect thymocyte development". Immunity. 9 (5): 657–68. doi:10.1016/S1074-7613(00)80663-9. PMID 9846487.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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