STYK1

Protein-coding gene in the species Homo sapiens

STYK1

Identifiers

Aliases

STYK1, NOK, SuRTK106, serine/threonine/tyrosine kinase 1

External IDs

OMIM: 611433; MGI: 2141396; HomoloGene: 49545; GeneCards: STYK1; OMA:STYK1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.2	Start	10,618,923 bp^[1]
Band	12p13.2	End	10,674,318 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 F3	Start	131,276,105 bp^[2]
Band	6\|6 F3	End	131,330,560 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

amniotic fluid

pancreatic ductal cell

rectum

middle temporal gyrus

Brodmann area 23

mucosa of colon

mucosa of transverse colon

mucosa of sigmoid colon

palpebral conjunctiva

Top expressed in

zygote

jejunum

left colon

secondary oocyte

primary oocyte

duodenum

Paneth cell

ileum

granulocyte

epithelium of stomach

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity protein tyrosine kinase activity signaling receptor binding non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity
Cellular component	integral component of membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane membrane
Biological process	peptidyl-tyrosine autophosphorylation cell differentiation protein phosphorylation innate immune response cell migration regulation of cell population proliferation phosphorylation chemotaxis cell adhesion epidermal growth factor receptor signaling pathway regulation of mast cell degranulation peptidyl-tyrosine phosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55359


243659

Ensembl


ENSG00000060140


ENSMUSG00000032899

UniProt


Q6J9G0


Q6J9G1

RefSeq (mRNA)


NM_018423


NM_172891

RefSeq (protein)


NP_060893


NP_766479

Location (UCSC)

Chr 12: 10.62 – 10.67 Mb

Chr 6: 131.28 – 131.33 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, Zeng L, Dai J, Wu Q, Gu S, Xie Y, Mao Y (Jul 2003). "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1". Mol Biol Rep. 30 (2): 91–6. doi:10.1023/A:1023934017174. PMID 12841579. S2CID 29762417.
^ "Entrez Gene: STYK1 serine/threonine/tyrosine kinase 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu L, Yu XZ, Li TS, et al. (2004). "A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice". Cancer Res. 64 (10): 3491–9. doi:10.1158/0008-5472.CAN-03-2106. PMID 15150103.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Amachika T, Kobayashi D, Moriai R, et al. (2007). "Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers". Lung Cancer. 56 (3): 337–40. doi:10.1016/j.lungcan.2007.01.002. PMID 17298854.

Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

ROR1
ROR2

DDR receptor family

DDR1
DDR2

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AATYK
AATYK2

AXL receptor family

RET receptor family

uncategorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG
ACK family	ACK1 TNK1
CSK family	CSK MATK
FAK family	FAK PYK2
FES family	FES FER
FRK family	FRK BRK SRMS
JAK family	JAK1 JAK2 JAK3 TYK2
SRC-A family	SRC FGR FYN YES1
SRC-B family	BLK HCK LCK LYN
TEC family	TEC BMX BTK ITK TXK
SYK family	SYK ZAP70