THRAP3

Protein-coding gene in the species Homo sapiens
THRAP3
Identifiers
AliasesTHRAP3, TRAP150, thyroid hormone receptor associated protein 3, BCLAF2
External IDsOMIM: 603809; MGI: 2442637; HomoloGene: 31289; GeneCards: THRAP3; OMA:THRAP3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for THRAP3
Genomic location for THRAP3
Band1p34.3Start36,224,416 bp[1]
End36,305,357 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for THRAP3
Genomic location for THRAP3
Band4|4 D2.2Start126,164,082 bp[2]
End126,202,760 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • ventricular zone

  • Achilles tendon

  • ganglionic eminence

  • stromal cell of endometrium

  • muscle of thigh

  • Descending thoracic aorta

  • gastric mucosa

  • right coronary artery

  • right lobe of thyroid gland
Top expressed in
  • tail of embryo

  • genital tubercle

  • ventricular zone

  • neural layer of retina

  • spermatocyte

  • yolk sac

  • epiblast

  • lip

  • Rostral migratory stream

  • muscle of thigh
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • transcription coactivator activity
  • transcription coregulator activity
  • thyroid hormone receptor binding
  • phosphoprotein binding
  • core promoter sequence-specific DNA binding
  • protein binding
  • nuclear receptor coactivator activity
  • ATP binding
  • vitamin D receptor binding
  • RNA binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • signaling receptor activity
Cellular component
  • nuclear speck
  • mediator complex
  • exon-exon junction complex
  • nucleoplasm
  • extracellular exosome
  • nucleus
Biological process
  • androgen receptor signaling pathway
  • regulation of transcription, DNA-templated
  • positive regulation of mRNA splicing, via spliceosome
  • rhythmic process
  • mRNA processing
  • intracellular steroid hormone receptor signaling pathway
  • regulation of alternative mRNA splicing, via spliceosome
  • transcription, DNA-templated
  • positive regulation of transcription, DNA-templated
  • nuclear-transcribed mRNA catabolic process
  • mRNA stabilization
  • circadian rhythm
  • RNA splicing
  • positive regulation of circadian rhythm
  • transcription initiation from RNA polymerase II promoter
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9967

230753

Ensembl

ENSG00000054118

ENSMUSG00000043962

UniProt

Q9Y2W1

Q569Z6

RefSeq (mRNA)

NM_005119
NM_001321471
NM_001321473

NM_146153
NM_001356455
NM_001356456

RefSeq (protein)

NP_001308400
NP_001308402
NP_005110

NP_666265
NP_001343384
NP_001343385

Location (UCSC)Chr 1: 36.22 – 36.31 MbChr 4: 126.16 – 126.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054118 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043962 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: THRAP3 thyroid hormone receptor associated protein 3".

Further reading

  • Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
  • Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  • Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
  • Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267. S2CID 23646963.
  • Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. Bibcode:2002Natur.417..563G. doi:10.1038/417563a. PMID 12037571. S2CID 4432077.
  • Johnson KM, Wang J, Smallwood A, et al. (2002). "TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA". Genes Dev. 16 (14): 1852–63. doi:10.1101/gad.995702. PMC 186393. PMID 12130544.
  • Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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