TOE1

Protein-coding gene in the species Homo sapiens
TOE1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2FC6

Identifiers
AliasesTOE1, hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease, TOE-1
External IDsOMIM: 613931; MGI: 1915526; HomoloGene: 11823; GeneCards: TOE1; OMA:TOE1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TOE1
Genomic location for TOE1
Band1p34.1Start45,340,052 bp[1]
End45,343,973 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TOE1
Genomic location for TOE1
Band4|4 D1Start116,651,507 bp[2]
End116,664,837 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory bulb

  • gonad

  • parotid gland

  • mucosa of transverse colon

  • right lobe of thyroid gland

  • left testis

  • granulocyte

  • right testis

  • smooth muscle tissue

  • rectum
Top expressed in
  • primitive streak

  • renal corpuscle

  • morula

  • blastocyst

  • spermatocyte

  • epiblast

  • superior cervical ganglion

  • medullary collecting duct

  • seminal vesicula

  • ureter
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • 3'-5'-exoribonuclease activity
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • poly(A)-specific ribonuclease activity
  • snRNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • Cajal body
  • nuclear speck
  • nucleolus
  • nucleoplasm
  • nucleus
  • nuclear body
Biological process
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • snRNA 3'-end processing
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114034

68276

Ensembl

ENSG00000132773

ENSMUSG00000028688

UniProt

Q96GM8

Q9D2E2

RefSeq (mRNA)

NM_025077

NM_026654

RefSeq (protein)

NP_079353

NP_080930

Location (UCSC)Chr 1: 45.34 – 45.34 MbChr 4: 116.65 – 116.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
  6. ^ "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
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