TTC8

Protein-coding gene in the species Homo sapiens
TTC8
Identifiers
AliasesTTC8, BBS8, RP51, tetratricopeptide repeat domain 8
External IDsOMIM: 608132; MGI: 1923510; HomoloGene: 14988; GeneCards: TTC8; OMA:TTC8 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for TTC8
Genomic location for TTC8
Band14q31.3Start88,824,153 bp[1]
End88,881,078 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TTC8
Genomic location for TTC8
Band12|12 EStart98,886,833 bp[2]
End98,949,497 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • islet of Langerhans

  • right adrenal cortex

  • right uterine tube

  • pituitary gland

  • right ovary

  • anterior pituitary

  • left adrenal gland

  • left adrenal cortex

  • stromal cell of endometrium
Top expressed in
  • neural layer of retina

  • olfactory epithelium

  • genital tubercle

  • median eminence

  • arcuate nucleus

  • pineal gland

  • tail of embryo

  • habenula

  • paraventricular nucleus of hypothalamus

  • dorsomedial hypothalamic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • ciliary basal body
  • cytosol
  • centrosome
  • plasma membrane
  • cell projection
  • cilium
  • cytoskeleton
  • membrane
  • ciliary membrane
  • microtubule organizing center
  • BBSome
  • non-motile cilium
  • photoreceptor connecting cilium
Biological process
  • protein transport
  • establishment of anatomical structure orientation
  • sensory processing
  • cell projection organization
  • cilium assembly
  • non-motile cilium assembly
  • axon guidance
  • sensory perception of smell
  • olfactory bulb development
  • negative regulation of GTPase activity
  • camera-type eye photoreceptor cell differentiation
  • renal tubule development
  • fat cell differentiation
  • regulation of stress fiber assembly
  • multicellular organism growth
  • regulation of protein localization
  • establishment of planar polarity
  • inner ear receptor cell stereocilium organization
  • multi-ciliated epithelial cell differentiation
  • protein localization to plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

123016

76260

Ensembl

ENSG00000165533

ENSMUSG00000021013

UniProt

Q8TAM2

Q8VD72

RefSeq (mRNA)
NM_001288781
NM_001288782
NM_001288783
NM_144596
NM_198309

NM_198310
NM_001366535
NM_001366536

NM_029553
NM_198311
NM_001364378

RefSeq (protein)
NP_001275710
NP_001275711
NP_001275712
NP_653197
NP_938051

NP_938052
NP_001353464
NP_001353465
NP_001275710.1

NP_083829
NP_938053
NP_001351307

Location (UCSC)Chr 14: 88.82 – 88.88 MbChr 12: 98.89 – 98.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetratricopeptide repeat domain 8 (TTC8) also known as Bardet–Biedl syndrome 8 is a protein that in humans is encoded by the TTC8 gene.[5]

Function

TTC8 is associated with gamma-tubulin, BBS4, and PCM1 in the centrosome.[5] PCM1 in turn is involved in centriolar replication during ciliogenesis.[6]

TTC8 is located in the cilia of spermatids, retina, and bronchial epithelium cells.[5]

Clinical significance

Mutations in the TTC8 gene is one of 14 genes[7] identified as causal for Bardet–Biedl syndrome.[5][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165533 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021013 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d Ansley SJ, Badano JL, Blacque OE, Hill J, Hoskins BE, Leitch CC, Kim JC, Ross AJ, Eichers ER, Teslovich TM, Mah AK, Johnsen RC, Cavender JC, Lewis RA, Leroux MR, Beales PL, Katsanis N (October 2003). "Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome". Nature. 425 (6958): 628–33. Bibcode:2003Natur.425..628A. doi:10.1038/nature02030. PMID 14520415. S2CID 4310157.
  6. ^ Kubo A, Sasaki H, Yuba-Kubo A, Tsukita S, Shiina N (November 1999). "Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis". J. Cell Biol. 147 (5): 969–80. doi:10.1083/jcb.147.5.969. PMC 2169353. PMID 10579718.
  7. ^ Hamosh A (2012-11-02). "OMIM entry #209900 Bardet-Biedl Syndrome; BBS". Online Mendelian Inheritance in Man. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine. Retrieved 2013-09-04.
  8. ^ Stoetzel C, Laurier V, Faivre L, Mégarbané A, Perrin-Schmitt F, Verloes A, Bonneau D, Mandel JL, Cossee M, Dollfus H (2006). "BBS8 is rarely mutated in a cohort of 128 Bardet-Biedl syndrome families". J. Hum. Genet. 51 (1): 81–4. doi:10.1007/s10038-005-0320-2. PMID 16308660.

Further reading

  • Nachury MV, Loktev AV, Zhang Q, et al. (2007). "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis". Cell. 129 (6): 1201–13. doi:10.1016/j.cell.2007.03.053. PMID 17574030.
  • Chung WK, Patki A, Matsuoka N, et al. (2009). "Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations". Hum. Hered. 67 (3): 193–205. doi:10.1159/000181158. PMC 2715950. PMID 19077438.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Riazuddin SA, Iqbal M, Wang Y, et al. (2010). "A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa". Am. J. Hum. Genet. 86 (5): 805–12. doi:10.1016/j.ajhg.2010.04.001. PMC 2869005. PMID 20451172.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bin J, Madhavan J, Ferrini W, et al. (2009). "BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population". Hum. Mutat. 30 (7): E737–46. doi:10.1002/humu.21040. PMID 19402160. S2CID 11446097.

External links

  • GeneReviews/NIH/NCBI/UW entry on Bardet–Biedl Syndrome a
  • TTC8 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)


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