UGT1A9

UGT1A9
Identifiers
Aliases	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I, UGT1A9S, UDP glucuronosyltransferase family 1 member A9
External IDs	OMIM: 606434; MGI: 3580642; HomoloGene: 133281; GeneCards: UGT1A9; OMA:UGT1A9 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,671,898 bp[1] End 233,773,300 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 87,983,110 bp[2] End 88,146,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver renal cortex human kidney mucosa of transverse colon rectum urinary bladder olfactory zone of nasal mucosa duodenum body of stomach islet of Langerhans Top expressed in renal cortex nephron proximal tubule renal medulla human kidney hair renal pelvis metanephros lateral recess right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity enzyme inhibitor activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity glucuronosyltransferase activity protein heterodimerization activity enzyme binding UDP-glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process retinoic acid metabolic process negative regulation of cellular glucuronidation cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation flavone metabolic process xenobiotic metabolic process negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process regulation of lipid metabolic process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54600 394430 Ensembl ENSG00000241119 ENSMUSG00000090165 UniProt O60656 n/a RefSeq (mRNA) NM_021027 NM_201641 RefSeq (protein) NP_066307 n/a Location (UCSC) Chr 2: 233.67 – 233.77 Mb Chr 1: 87.98 – 88.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UDP-glucuronosyltransferase 1-9 is an enzyme that in humans is encoded by the UGT1A9 gene.^[5][6][7][8]

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

Medicinal Chemistry Case Studies

During hit optimization of HSD17B13 inhibitors significant glucuronidation of the phenol moiety was observed in vitro and in vivo.^[9] UGT phenotyping revealed UGT1A9 as main contributor for glucuronidation. In addition, tissue distribution as well as bile excretion studies were performed.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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