Wd repeat domain 76

Protein-coding gene in the species Homo sapiens
WDR76
Identifiers
AliasesWDR76, CDW14, WD repeat domain 76
External IDsMGI: 1926186; HomoloGene: 38573; GeneCards: WDR76; OMA:WDR76 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for WDR76
Genomic location for WDR76
Band15q15.3Start43,826,980 bp[1]
End43,868,412 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for WDR76
Genomic location for WDR76
Band2|2 E5Start121,337,204 bp[2]
End121,375,341 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • ganglionic eminence

  • secondary oocyte

  • endothelial cell

  • Achilles tendon

  • bone marrow cells

  • stromal cell of endometrium

  • lymph node

  • rectum

  • body of pancreas
Top expressed in
  • secondary oocyte

  • superior cervical ganglion

  • thymus

  • hand

  • yolk sac

  • cumulus cell

  • ganglionic eminence

  • abdominal wall

  • spleen

  • primitive streak
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • enzyme binding
Cellular component
  • nucleus
  • heterochromatin
  • site of DNA damage
Biological process
  • cellular response to DNA damage stimulus
  • regulation of DNA damage checkpoint
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79968

241627

Ensembl

ENSG00000092470

ENSMUSG00000027242

UniProt

Q9H967

A6PWY4

RefSeq (mRNA)

NM_001167941
NM_024908

NM_001290986
NM_001290987
NM_030234
NM_001369185

RefSeq (protein)

NP_001161413
NP_079184

NP_001277915
NP_001277916
NP_084510
NP_001356114

Location (UCSC)Chr 15: 43.83 – 43.87 MbChr 2: 121.34 – 121.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat domain 76 is a protein that in humans is encoded by the WDR76 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092470 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027242 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: WD repeat domain 76". Retrieved 2018-04-16.

Further reading

  • Fleischmann C, Bevan S, Neil JC, Terry A, Houlston RS (June 2003). "Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer". Cancer Lett. 196 (1): 65–7. doi:10.1016/s0304-3835(03)00160-5. PMID 12860291.
  • Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
  • Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.


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