Angiotentsinaren entzima bihurtzaile

ACE
Proteinak kodetzen dituen genea

Identifikadoreak
Homologene: 37351 Genenames: ACE Ensemble: ENSG00000159640
Taxoia	Homo sapiens
Asoziazio-genetikoa	diabetic nephropathy ^(en) hipertentsio
Kokapena
Kromosoma	human chromosome 17 ^(en)

Kokapen zitogenetikoa	17q23.3
Hasiera	63477061 bp^[1]
Amaiera	63498380 bp^[2]

Transkripzioak
RNA ID	XM_006721737, NM_000789, NM_001178057, NM_152830, NM_152831, NM_001382700, NM_001382701, NM_001382702 eta NR_168483
Ensembl	Zerrenda ENST00000584865 ENST00000290863 ENST00000290866 ENST00000413513 ENST00000428043 ENST00000577418 ENST00000578679 ENST00000578839 ENST00000579204 ENST00000579314 ENST00000579462 ENST00000579726 ENST00000580318 ENST00000582005 ENST00000582244 ENST00000582627 ENST00000582678 ENST00000582761 ENST00000583336 ENST00000583645 ENST00000584529

Sagu arrunt	Ace ^(en)

Arratoi arrunt	Ace ^(en)

Danio rerio	ace ^(en)

Ontologia
Kodetzen du	angiotentsinaren entzima bihurtzaile
Funtzio-molekularrak	Ikusi tripeptidyl-peptidase activity ^(en) zinc ion binding ^(en) exopeptidase activity ^(en) endopeptidase activity ^(en) metal ion binding ^(en) mitogen-activated protein kinase binding ^(en) bradykinin receptor binding ^(en) peptidase activity ^(en) proteina lotura carboxypeptidase activity ^(en) chloride ion binding ^(en) actin binding ^(en) mitogen-activated protein kinase kinase binding ^(en) hydrolase activity ^(en) metallodipeptidase activity ^(en) metallopeptidase activity ^(en) peptidyl-dipeptidase activity ^(en) metallopeptidase activity ^(en) exopeptidase activity ^(en) dipeptidyl-peptidase activity ^(en) peptidyl-dipeptidase activity ^(en)
Osagai-zelularra	Ikusi zitoplasma zelula-mintzaren osagai integrala endosoma mintza Lisosoma extracellular exosome ^(en) external side of plasma membrane ^(en) zelulaz kanpoko eremu zelula mintz extracellular space ^(en) extracellular space ^(en) zelula mintz extracellular exosome ^(en)
Prozesu-biologikoak	Ikusi regulation of renal output by angiotensin ^(en) antigen processing and presentation of peptide antigen via MHC class I ^(en) amyloid-beta metabolic process ^(en) angiotensin maturation ^(en) blood vessel remodeling ^(en) regulation of vasoconstriction ^(en) hematopoietic stem cell differentiation ^(en) regulation of angiotensin metabolic process ^(en) regulation of smooth muscle cell migration ^(en) mononuclear cell proliferation ^(en) regulation of systemic arterial blood pressure by renin-angiotensin ^(en) arachidonic acid secretion ^(en) peptide catabolic process ^(en) blood vessel diameter maintenance ^(en) proteolisi kidney development ^(en) neutrophil mediated immunity ^(en) positive regulation of systemic arterial blood pressure ^(en) Espermatogenesi regulation of blood pressure ^(en) posttranscriptional regulation of gene expression ^(en) negative regulation of gene expression ^(en) negative regulation of protein binding ^(en) positive regulation of protein binding ^(en) hormone catabolic process ^(en) heart contraction ^(en) positive regulation of protein tyrosine kinase activity ^(en) cell proliferation in bone marrow ^(en) positive regulation of peptidyl-tyrosine autophosphorylation ^(en) regulation of hematopoietic stem cell proliferation ^(en) negative regulation of gap junction assembly ^(en) positive regulation of peptidyl-cysteine S-nitrosylation ^(en) angiotensin maturation ^(en) regulation of systemic arterial blood pressure by renin-angiotensin ^(en) positive regulation of systemic arterial blood pressure ^(en) positive regulation of blood pressure ^(en)

Angiotentsinaren entzima bihurtzailea (AEB edo ACE) I angiotentsina izeneko substantzia II angiotentsina (giza gorputzeko hodi-uzkurtzailerik indartsuena) bihurtzen duen entzima da. Bradikinina hipotentsorearen inaktibazioa estimulatzen duen II kininasaren berdina da entzima hori, eta, beraz, AEBak funtsezko eginkizuna du presio arterialaren erregulazioan.^[3]. Hainbat gorputz-ehunek sortzen dute, hala nola nerbio-sistema zentralak, giltzurrunak eta birikak.

Erreferentziak

↑ GRCh38: Ensembl release 89: ENSG00000159640. Ensembl.
↑ GRCh38: Ensembl release 89: ENSG00000159640. Ensembl.
↑ Euskalterm: [Kardiologia Hiztegia] [2023]

Kanpo estekak

Autoritate kontrola	Wikimedia proiektuak Datuak: Q128861 Multimedia: Angiotensin converting enzyme, ACE / Q128861 Identifikadoreak NKC: ph250750 Medikuntzako identifikadoreak MeSH: D007703