Catecol O-Metiltransferase

COMT
Estruturas disponíveis
PDBPesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB

4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

Identificadores
Nomes alternativosCOMT
IDs externosOMIM: 116790 HomoloGene: 30982 GeneCards: COMT
Targeted by Drug
entacapone, tolcapona, Viroporin 3a[1]
Ontologia genética
Função molecular• transferase activity
• O-methyltransferase activity
• metal ion binding
• GO:0001948, GO:0016582 ligação a proteínas plasmáticas
• magnesium ion binding
• catechol O-methyltransferase activity
• GO:0102674, GO:0102675 methyltransferase activity
• L-dopa O-methyltransferase activity
• orcinol O-methyltransferase activity
Componente celular• citoplasma
• integral component of membrane
• corpo celular
• citosol
• postsynaptic membrane
• membrane
• membrana plasmática
• Espinha dendrítica
• axónio
• dendrito
• mitocôndria
• Exossoma
• intracellular membrane-bounded organelle
Processo biológico• multicellular organismal reproductive process
• negative regulation of smooth muscle cell proliferation
• GO:1904578 response to organic cyclic compound
• regulation of sensory perception of pain
• estrogen metabolic process
• cellular response to phosphate starvation
• catechol-containing compound metabolic process
• female pregnancy
• negative regulation of dopamine metabolic process
• GO:0007571 developmental process
• aprendizagem
• catecholamine metabolic process
• neurotransmitter catabolic process
• response to lipopolysaccharide
• metilação
• dopamine metabolic process
• response to pain
• memória a curto prazo
• negative regulation of renal sodium excretion
• dopamine catabolic process
• positive regulation of homocysteine metabolic process
• catecholamine catabolic process
• response to estrogen
Sources:Amigo / QuickGO
Padrão de expressão RNA




Mais dados de referência de expressão
Ortólogos
EspécieHumanoRato
Entrez

1312

n/a

Ensembl

ENSG00000093010

n/a

UniProt

P21964

n/a

RefSeq (mRNA)

NM_000754
NM_001135161
NM_001135162
NM_007310
NM_001362828

n/a

RefSeq (proteína)

NP_000745
NP_001128633
NP_001128634
NP_009294
NP_001349757

n/a

Localização (UCSC)n/an/a
Pesquisa PubMed[2]n/a
Wikidata
Ver/Editar Humano

A Catecol O-Metiltransferase, ou simplesmente COMT, é uma das muitas enzimas que degradam catecolaminas (dopamina, epinefrina e norepinefrina).[3]

Referências

  1. ↑ «Drogas que interagem fisicamente com Catechol-O-methyltransferase ver/editar referências no wikidata» 
  2. ↑ «Human PubMed Reference:» 
  3. ↑ «Test ID: COMT: Catechol-O-Methyltransferase Genotype». www.mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Consultado em 16 de novembro de 2016. Arquivado do original em 18 de setembro de 2008 
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Leitura adicional

  • Trendelenburg U (1991). «The interaction of transport mechanisms and intracellular enzymes in metabolizing systems». Journal of Neural Transmission. Supplementum. 32: 3–18. ISBN 978-3-211-82239-5. PMID 2089098. doi:10.1007/978-3-7091-9113-2_1 
  • Zhu BT (outubro de 2002). «On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis». Histology and Histopathology. 17 (4): 1283–91. PMID 12371153 
  • Oroszi G, Goldman D (dezembro de 2004). «Alcoholism: genes and mechanisms». Pharmacogenomics. 5 (8): 1037–48. PMID 15584875. doi:10.1517/14622416.5.8.1037 
  • Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (janeiro de 2005). «Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis». Biological Psychiatry. 57 (2): 139–44. PMID 15652872. doi:10.1016/j.biopsych.2004.10.018 
  • Tunbridge EM, Harrison PJ, Weinberger DR (julho de 2006). «Catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond». Biological Psychiatry. 60 (2): 141–51. PMID 16476412. doi:10.1016/j.biopsych.2005.10.024 
  • Craddock N, Owen MJ, O'Donovan MC (maio de 2006). «The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons». Molecular Psychiatry. 11 (5): 446–58. PMID 16505837. doi:10.1038/sj.mp.4001808 
  • Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE (outubro de 2007). «Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning». Proceedings of the National Academy of Sciences of the United States of America. 104 (41): 16311–6. PMC 2042203Acessível livremente. PMID 17913879. doi:10.1073/pnas.0706111104 
  • Greenberg, Gary (7 de novembro de 2018). «What If the Placebo Effect Isn't a Trick?». New York Times Magazine