POLR2L

POLR2L
Estruturas disponíveis
PDBPesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB

5FLM, 5IYD, 5IYC, 5IY8, 5IYA, 5IYB, 5IY6, 5IY9, 5IY7

Identificadores
Nomes alternativosPOLR2L
IDs externosOMIM: 601189 HomoloGene: 129854 GeneCards: POLR2L
Ontologia genética
Função molecular• DNA binding
• zinc ion binding
• RNA polymerase II activity
• metal ion binding
• RNA polymerase III activity
• DNA-directed 5'-3' RNA polymerase activity
• GO:0001948, GO:0016582 ligação a proteínas plasmáticas
• RNA polymerase I activity
Componente celular• citosol
• cariolinfa
• RNA polymerase I complex
• RNA polymerase III complex
• RNA polimerase II
• núcleo celular
Processo biológico• termination of RNA polymerase I transcription
• mRNA splicing, via spliceosome
• epigenetic maintenance of chromatin in transcription-competent conformation
• regulation of transcription by RNA polymerase I
• transcription initiation from RNA polymerase I promoter
• transcription elongation from RNA polymerase II promoter
• 7-methylguanosine mRNA capping
• transcription by RNA polymerase II
• transcription-coupled nucleotide-excision repair
• transcription initiation from RNA polymerase II promoter
• fibroblast growth factor receptor signaling pathway
• transcription by RNA polymerase III
• snRNA transcription by RNA polymerase II
• RNA metabolic process
• GO:1905616 regulation of gene silencing by miRNA
• transcription, DNA-templated
• GO:0001183 transcription elongation from RNA polymerase I promoter
• positive regulation of type I interferon production
• somatic stem cell population maintenance
• positive regulation of viral transcription
Sources:Amigo / QuickGO
Padrão de expressão RNA


Mais dados de referência de expressão
Ortólogos
EspécieHumanoRato
Entrez

5441

n/a

Ensembl

ENSG00000177700

n/a

UniProt

P62875

n/a

RefSeq (mRNA)

NM_021128

n/a

RefSeq (proteína)

NP_066951

n/a

Localização (UCSC)n/an/a
Pesquisa PubMed[1]n/a
Wikidata
Ver/Editar Humano

As subunidades RPABC5 das polimerases I, II e III do RNA dirigidas pelo DNA são proteínas que, em humanos, são codificadas pelo gene POLR2L.[2]

Função

Este gene codifica uma subunidade da polimerase II do RNA, a polimerase responsável pela síntese do RNA mensageiro em eucariotos. O produto deste gene contém quatro cisteínas conservadas características de um domínio atípico de ligação ao zinco. Como sua contraparte na levedura, esta subunidade pode ser compartilhada pelas outras duas polimerases do RNA dirigidas pelo DNA.[3]

Interações

Foi demonstrado que POLR2L interage com POLR2C,[4] POLR2A,[4] POLR2B[4] e POLR2E.[4]

Referências

  1. ↑ «Human PubMed Reference:» 
  2. ↑ Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (setembro de 1996). «The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase». Genomics. 32 (1): 86–90. PMID 8786124. doi:10.1006/geno.1996.0079 
  3. ↑ «Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa» 
  4. ↑ a b c d Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (julho de 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. 272 (27): 16815–21. PMID 9201987. doi:10.1074/jbc.272.27.16815 

Bibliografia

  • Jeang KT (1998). «Tat, Tat-associated kinase, and transcription.». J. Biomed. Sci. 5 (1): 24–7. PMID 9570510. doi:10.1007/BF02253352 
  • Yankulov K, Bentley D (1998). «Transcriptional control: Tat cofactors and transcriptional elongation.». Curr. Biol. 8 (13): R447–9. PMID 9651670. doi:10.1016/S0960-9822(98)70289-1 
  • Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). «Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression». J. Cell. Biochem. 75 (3): 357–68. PMID 10536359. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K 
  • Marcello A, Zoppé M, Giacca M (2002). «Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator». IUBMB Life. 51 (3): 175–81. PMID 11547919. doi:10.1080/152165401753544241 
  • Stevens M, De Clercq E, Balzarini J (2007). «The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention». Med Res Rev. 26 (5): 595–625. PMC 7168390Acessível livremente. PMID 16838299. doi:10.1002/med.20081 
  • Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). «Will diverse Tat interactions lead to novel antiretroviral drug targets?». Current Drug Targets. 7 (12): 1595–606. PMID 17168834. doi:10.2174/138945006779025338 
  • Jang KL, Collins MK, Latchman DS (1992). «The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC». J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646 
  • Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). «HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors». Genes Dev. 6 (4): 655–66. PMID 1559613. doi:10.1101/gad.6.4.655 
  • Southgate C, Zapp ML, Green MR (1990). «Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein». Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. PMID 2190099. doi:10.1038/345640a0 
  • Wu-Baer F, Sigman D, Gaynor RB (1995). «Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat». Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. PMC 41297Acessível livremente. PMID 7638159. doi:10.1073/pnas.92.16.7153 
  • Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M (1995). «Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae». Mol. Cell. Biol. 15 (9): 4702–10. PMC 230713Acessível livremente. PMID 7651387. doi:10.1128/mcb.15.9.4702 
  • Herrmann CH, Rice AP (1995). «Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor». J. Virol. 69 (3): 1612–20. PMC 188757Acessível livremente. PMID 7853496. doi:10.1128/JVI.69.3.1612-1620.1995 
  • McKune K, Moore PA, Hull MW, Woychik NA (1996). «Six human RNA polymerase subunits functionally substitute for their yeast counterparts». Mol. Cell. Biol. 15 (12): 6895–900. PMC 230944Acessível livremente. PMID 8524256. doi:10.1128/mcb.15.12.6895 
  • Keen NJ, Gait MJ, Karn J (1996). «Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex». Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. PMC 39827Acessível livremente. PMID 8637904. doi:10.1073/pnas.93.6.2505 
  • Yang X, Herrmann CH, Rice AP (1996). «The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function». J. Virol. 70 (7): 4576–84. PMC 190394Acessível livremente. PMID 8676484. doi:10.1128/JVI.70.7.4576-4584.1996 
  • Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). «The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB». J. Mol. Biol. 261 (5): 599–606. PMID 8800208. doi:10.1006/jmbi.1996.0485 
  • Zhou Q, Sharp PA (1996). «Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat». Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. PMID 8849451. doi:10.1126/science.274.5287.605 
  • Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). «Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II». Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. PMC 38099Acessível livremente. PMID 8876177. doi:10.1073/pnas.93.21.11575 
  • Chun RF, Jeang KT (1996). «Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1». J. Biol. Chem. 271 (44): 27888–94. PMID 8910388. doi:10.1074/jbc.271.44.27888 
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Identificadores