Akonitaza
| Akonitat hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Ilustracija akonitaze svinje u kompleksu sa [Fe4S4] klusterom.[1] | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.3 | ||||||||
| CAS broj | 9024-25-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
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Akonitaza je trivijalni naziv za gvožđe-sumporni enzim akonitat hidratazu (citrat hidrolijazu, EC 4.2.1.3) koji katalizuje reverzibilne reakcije stereospecifične izomerizacije citrata, cis-akonitata i izocitrata u Krebsovom ciklusu.[2][3][4]
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Limunska kiselina -
Akonitinska kiselina -
Reference
- ↑ PDB 7ACN; Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. (1992). „Crystal structures of aconitase with isocitrate and nitroisocitrate bound”. Biochemistry 31 (10): 2735–48. DOI:10.1021/bi00125a014. PMID 1547214.
- ↑ Beinert, H; Kennedy, MC (1993). „Aconitase, a two-faced protein: Enzyme and iron regulatory factor”. The FASEB Journal 7 (15): 1442–9. PMID 8262329.
- ↑ Flint, Dennis H.; Allen, Ronda M. (1996). „Iron−Sulfur Proteins with Nonredox Functions”. Chemical Reviews 96 (7): 2315–34. DOI:10.1021/cr950041r.
- ↑ Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David (1996). „Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein”. Chemical Reviews 96 (7): 2335–74. DOI:10.1021/cr950040z. PMID 11848830.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
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Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
