BLZF1

Protein-coding gene in the species Homo sapiens
BLZF1
Identifiers
AliasesBLZF1, GOLGIN-45, JEM-1, JEM-1s, JEM1, basic leucine zipper nuclear factor 1
External IDsOMIM: 608692; MGI: 1201607; HomoloGene: 31187; GeneCards: BLZF1; OMA:BLZF1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for BLZF1
Genomic location for BLZF1
Band1q24.2Start169,367,970 bp[1]
End169,396,540 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for BLZF1
Genomic location for BLZF1
Band1|1 H2.2Start164,117,369 bp[2]
End164,135,058 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • gonad

  • buccal mucosa cell

  • epithelium of colon

  • oral cavity

  • mucosa of esophagus

  • gallbladder

  • rectum

  • superficial temporal artery

  • islet of Langerhans
Top expressed in
  • lumbar spinal ganglion

  • zygote

  • secondary oocyte

  • esophagus

  • genital tubercle

  • muscle of thigh

  • cardiac muscle tissue of left ventricle

  • neural layer of retina

  • tail of embryo

  • spermatid
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • enzyme binding
  • DNA binding
  • protein binding
  • ubiquitin protein ligase binding
Cellular component
  • cytoplasm
  • Golgi lumen
  • nucleus
  • Golgi apparatus
  • Golgi membrane
  • membrane
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • Golgi to plasma membrane protein transport
  • protein transport
  • cell population proliferation
  • Golgi organization
  • regulation of cell growth
  • vesicle-mediated transport
  • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8548

66352

Ensembl

ENSG00000117475

ENSMUSG00000026577

UniProt

Q9H2G9
Q5T532

Q8R2X8

RefSeq (mRNA)

NM_003666
NM_001320972
NM_001320973

NM_001160208
NM_001160209
NM_025505
NM_001357052

RefSeq (protein)

NP_001307901
NP_001307902
NP_003657

NP_001153680
NP_001153681
NP_079781
NP_001343981

Location (UCSC)Chr 1: 169.37 – 169.4 MbChr 1: 164.12 – 164.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.[5][6]

Interactions

BLZF1 has been shown to interact with GORASP2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117475 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026577 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duprez E, Tong JH, Dérré J, Chen SJ, Berger R, Chen Z, Lanotte M (May 1997). "JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia". Oncogene. 14 (13): 1563–70. doi:10.1038/sj.onc.1200995. PMID 9129147.
  6. ^ "Entrez Gene: BLZF1 basic leucine zipper nuclear factor 1 (JEM-1)".
  7. ^ Barr FA, Preisinger C, Kopajtich R, Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
  • Tong JH, Fant X, Duprez E, Benoit G, Uphoff CC, Drexler HG, Pla JC, Lofvenberg E, Lanotte M (1998). "Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells". Leukemia. 12 (11): 1733–40. doi:10.1038/sj.leu.2401173. PMID 9823948.
  • Tong JH, Duprez E, Lanotte M (1999). "JEM-1, a novel nuclear co-factor: localisation and functional interaction with AP-1". Leukemia. 13 (12): 1982–92. doi:10.1038/sj/leu/2401560. PMID 10602419.
  • Tong JH, Fant X, Benoit G, Chen SJ, Chen Z, Lanotte M (2000). "Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region". Genomics. 69 (3): 380–90. doi:10.1006/geno.2000.6347. PMID 11056056.
  • Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
  • Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e