Bay K8644
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Preferred IUPAC name Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate | |
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ChEBI |
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ECHA InfoCard | 100.163.930 |
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Properties | |
Chemical formula | C16H15F3N2O4 |
Molar mass | 356.301 g·mol−1 |
Solubility in water | Insoluble |
Solubility in other solvents | DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL |
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H315, H319 | |
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.
Mechanism of action
Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]
References
- ^ (±)-Bay K8644 at Sigma-Aldrich
- ^ CID 2303 from PubChem
- ^ Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent". Circ Res. 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.
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VGKCsTooltip Voltage-gated potassium channels |
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IRKsTooltip Inwardly rectifying potassium channel |
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KCaTooltip Calcium-activated potassium channel |
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K2PsTooltip Tandem pore domain potassium channel |
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VGSCsTooltip Voltage-gated sodium channels |
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ENaCTooltip Epithelial sodium channel |
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ASICsTooltip Acid-sensing ion channel |
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CaCCsTooltip Calcium-activated chloride channel |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator |
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Unsorted |
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TRPsTooltip Transient receptor potential channels |
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LGICsTooltip Ligand gated ion channels |
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators
This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it. |
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