Nitrosourea
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Names | |||
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IUPAC name Nitrosourea | |||
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InChI
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Properties | |||
Chemical formula | CH3N3O2 | ||
Molar mass | 89.054 g·mol−1 | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.
Examples
Examples include:
- Arabinopyranosyl-N-methyl-N-nitrosourea (Aranose)
- Carmustine (BCNU, BiCNU)
- Chlorozotocin
- Ethylnitrosourea (ENU)
- Fotemustine
- Lomustine (CCNU)
- Nimustine
- N-Nitroso-N-methylurea (NMU)
- Ranimustine (MCNU)
- Semustine
- Streptozocin (Streptozotocin)
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]
- Arabinopyranosyl-N-methyl-N-nitrosourea
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- N-Nitroso-N-methylurea
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Side effects
Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]
References
- ^ "Antineop". Archived from the original on 2009-03-07. Retrieved 2009-01-24.
- ^ Takimoto CH, Calvo E. "Principles of oncologic pharmacotherapy". in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer management: a multidisciplinary approach. 11 ed. 2008.
- ^ Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis". Tumori. 72 (1): 95–8. doi:10.1177/030089168607200114. PMID 3952821. S2CID 33327504.
External links
- Nitrosourea+Compounds at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Diseases Database (DDB): 9052
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(M phase)
Block microtubule assembly | |
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Block microtubule disassembly |
inhibitor
DNA precursors/ antimetabolites (S phase) |
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Topoisomerase inhibitors (S phase) |
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Crosslinking of DNA (CCNS) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
This article about an organic compound is a stub. You can help Wikipedia by expanding it. |
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