Pyrimidine analogue
Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
Examples
- Nucleobase analogues
- Fluorouracil (5FU), which inhibits thymidylate synthase
- Floxuridine (FUDR)
- 6-azauracil (6-AU)
- Nucleoside analogues
- Cytarabine (Cytosine arabinoside)
- Gemcitabine
- Nucleotide analogues
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Pyrimidine -
Fluorouracil -
Floxuridine -
Gemcitabine
Medical uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
- ^ Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 (7): 2880–2893. doi:10.1021/cr900028p. PMC 2827868. PMID 19476376.
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Intracellular chemotherapeutic agents / antineoplastic agents (L01)
(M phase)
| Block microtubule assembly | |
|---|---|
| Block microtubule disassembly |
inhibitor
| DNA precursors/ antimetabolites (S phase) |
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| Topoisomerase inhibitors (S phase) |
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| Crosslinking of DNA (CCNS) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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