BBX (gene)

Human protein-coding gene
BBX
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WZ6

Identifiers
AliasesBBX, ARTC1, HBP2, HSPC339, MDS001, bobby sox homolog (Drosophila), HMG-box containing
External IDsMGI: 1917758; HomoloGene: 10634; GeneCards: BBX; OMA:BBX - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for BBX
Genomic location for BBX
Band3q13.12Start107,522,936 bp[1]
End107,811,324 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for BBX
Genomic location for BBX
Band16|16 B5Start50,012,207 bp[2]
End50,252,753 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • tail of epididymis

  • caput epididymis

  • corpus callosum

  • lactiferous duct

  • inferior ganglion of vagus nerve

  • seminal vesicula

  • Achilles tendon

  • saphenous vein

  • testicle
Top expressed in
  • cumulus cell

  • spermatid

  • ascending aorta

  • pineal gland

  • pituitary gland

  • seminiferous tubule

  • aortic valve

  • lumbar spinal ganglion

  • stroma of bone marrow

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • bone development
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56987

70508

Ensembl

ENSG00000114439

ENSMUSG00000022641

UniProt

Q8WY36

Q8VBW5

RefSeq (mRNA)

NM_001142568
NM_001276286
NM_020235

NM_027444
NM_001347240

RefSeq (protein)

NP_001136040
NP_001263215
NP_064620

NP_001334169
NP_081720

Location (UCSC)Chr 3: 107.52 – 107.81 MbChr 16: 50.01 – 50.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HMG box transcription factor BBX also known as bobby sox homolog or HMG box-containing protein 2 is a protein that in humans is encoded by the BBX gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114439 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022641 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: bobby sox homolog (Drosophila)". Retrieved 2011-08-30.

External links

Further reading

  • Caporaso N, Gu F, Chatterjee N, Sheng-Chih J, Yu K, Yeager M, Chen C, Jacobs K, Wheeler W, Landi MT, Ziegler RG, Hunter DJ, Chanock S, Hankinson S, Kraft P, Bergen AW (2009). "Genome-wide and candidate gene association study of cigarette smoking behaviors". PLOS ONE. 4 (2): e4653. Bibcode:2009PLoSO...4.4653C. doi:10.1371/journal.pone.0004653. PMC 2644817. PMID 19247474.
  • Wang HY, Peng G, Guo Z, Shevach EM, Wang RF (Mar 2005). "Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells". Journal of Immunology. 174 (5): 2661–70. doi:10.4049/jimmunol.174.5.2661. PMID 15728473.
  • Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (Aug 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Sánchez-Díaz A, Blanco MA, Jones N, Moreno S (Sep 2001). "HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex". Current Genetics. 40 (2): 110–8. doi:10.1007/s002940100241. PMID 11680820. S2CID 30444254.
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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