Bermekimab
Monoclonal antibody
- L01FX11 (WHO)
- 1401965-15-8
- DB14947
- none
- N6SVN735GY
- D11253
Bermekimab[1] (MABp1, trade name Xilonix) is a human monoclonal antibody of IgG1k isotype targeting Interleukin 1 alpha (IL1A).[2] As of March 2017[update], bermekimab is in phase III clinical trials as an immunotherapy for colorectal cancer[3] and as of September 2018 in phase II clinical trials for the treatment of atopic dermatitis.[4]
Bermekimab is being developed by XBiotech Inc.[5]
References
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Bermekimab, American Medical Association.
- ^ Hong DS, Hui D, Bruera E, Janku F, Naing A, Falchook GS, et al. (May 2014). "MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study". The Lancet. Oncology. 15 (6): 656–66. doi:10.1016/S1470-2045(14)70155-X. PMID 24746841.
- ^ Clinical trial number NCT01767857 for "A Phase III Study of Xilonix in Patients With Advanced Colorectal Cancer (XCITE)" at ClinicalTrials.gov
- ^ Clinical trial number NCT03496974 for "A Phase II Study of Bermekimab (MABp1) in Patients With Moderate to Severe Atopic Dermatitis" at ClinicalTrials.gov
- ^ "Xilonix True Human monoclonal antibody by Xbiotech oncology". www.xbiotech.com. XBiotech. Retrieved 3 March 2017.
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Targeted cancer therapy / antineoplastic agents (L01)
Receptor tyrosine kinase |
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