CELSR2

CELSR2
Identifiers
Aliases	CELSR2, CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265; MGI: 1858235; HomoloGene: 1078; GeneCards: CELSR2; OMA:CELSR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,249,539 bp[1] End 109,275,751 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 47.02 cM Start 108,298,167 bp[2] End 108,323,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex hippocampus proper postcentral gyrus Brodmann area 9 superior frontal gyrus entorhinal cortex Region I of hippocampus proper right uterine tube skin of abdomen Top expressed in superior surface of tongue gallbladder lip subiculum superior frontal gyrus visual cortex motor neuron ascending aorta extensor digitorum longus muscle supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity calcium ion binding transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane membrane cytoplasm Biological process homophilic cell adhesion via plasma membrane adhesion molecules regulation of transcription, DNA-templated cell surface receptor signaling pathway multicellular organism development regulation of cell-cell adhesion Wnt signaling pathway, planar cell polarity pathway G protein-coupled receptor signaling pathway signal transduction neural plate anterior/posterior regionalization Wnt signaling pathway cell adhesion dendrite morphogenesis cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1952 53883 Ensembl ENSG00000143126 ENSMUSG00000068740 UniProt Q9HCU4 Q9R0M0 RefSeq (mRNA) NM_001408 NM_001004177 NM_017392 RefSeq (protein) NP_001399 NP_001004177 NP_059088 Location (UCSC) Chr 1: 109.25 – 109.28 Mb Chr 3: 108.3 – 108.32 Mb PubMed search [3] [4]
Wikidata
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Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.^[5][6]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.^[6]

See also

• Flamingo (protein)

References

Further reading

External links

• Human CELSR2 genome location and CELSR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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