Neuromedin B receptor

Protein-coding gene in the species Homo sapiens
NMBR
Identifiers
AliasesNMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDsOMIM: 162341; MGI: 1100525; HomoloGene: 20560; GeneCards: NMBR; OMA:NMBR - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for NMBR
Genomic location for NMBR
Band6q24.1Start142,058,330 bp[1]
End142,147,122 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • prefrontal cortex

  • olfactory zone of nasal mucosa

  • ganglionic eminence

  • right uterine tube

  • caudate nucleus

  • gonad

  • putamen

  • nucleus accumbens
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled peptide receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
  • bombesin receptor activity
Cellular component
  • integral component of plasma membrane
  • membrane
  • integral component of membrane
  • plasma membrane
  • cytosol
Biological process
  • phospholipase C-activating G protein-coupled receptor signaling pathway
  • bombesin receptor signaling pathway
  • signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4829

18101

Ensembl

ENSG00000135577

ENSMUSG00000019865

UniProt

P28336

O54799

RefSeq (mRNA)

NM_002511
NM_001324307
NM_001324308

NM_008703

RefSeq (protein)

NP_001311236
NP_001311237
NP_002502

NP_032729

Location (UCSC)Chr 6: 142.06 – 142.15 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB1 [4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135577 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-10-04. Retrieved 2007-10-25.
  5. ^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
  6. ^ "Entrez Gene: NMBR neuromedin B receptor".

Further reading

  • Corjay MH, Dobrzanski DJ, Way JM, et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells". J. Biol. Chem. 266 (28): 18771–9. doi:10.1016/S0021-9258(18)55129-2. PMID 1655761.
  • Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750.
  • Benya RV, Kusui T, Pradhan TK, et al. (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
  • Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction". Gastroenterology. 105 (6): 1672–80. doi:10.1016/0016-5085(93)91062-m. PMID 8253343.
  • Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. S2CID 20854144.
  • Fathi Z, Benya RV, Shapira H, et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding". J. Biol. Chem. 268 (20): 14622–6. doi:10.1016/S0021-9258(18)82378-X. PMID 8392057.
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. S2CID 30893871.
  • Sainz E, Akeson M, Mantey SA, et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639.
  • Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. S2CID 46035151.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Matusiak D, Glover S, Nathaniel R, et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253.

External links

  • "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-10-04. Retrieved 2007-10-25.
  • Receptors,+Bombesin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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