PEG3

Protein-coding gene in the species Homo sapiens
PEG3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4BHX

Identifiers
AliasesPEG3, PW1, ZKSCAN22, ZNF904, ZSCAN24, paternally expressed 3
External IDsOMIM: 601483 MGI: 104748 HomoloGene: 31363 GeneCards: PEG3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PEG3
Genomic location for PEG3
Band19q13.43Start56,810,077 bp[1]
End56,840,728 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PEG3
Genomic location for PEG3
Band7 A1|7 3.89 cMStart6,703,892 bp[2]
End6,730,431 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • superior vestibular nucleus

  • Brodmann area 23

  • pons

  • middle temporal gyrus

  • ventral tegmental area

  • external globus pallidus

  • cerebellar vermis

  • parietal lobe

  • entorhinal cortex
Top expressed in
  • belly cord

  • condyle

  • medullary collecting duct

  • pituitary gland

  • substantia nigra

  • ventromedial nucleus

  • fossa

  • dorsomedial hypothalamic nucleus

  • abdominal wall

  • dermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • nucleus
  • autophagosome
Biological process
  • apoptotic process
  • regulation of gene expression
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5178

18616

Ensembl

ENSG00000198300

ENSMUSG00000002265

UniProt

Q9GZU2

Q3URU2

RefSeq (mRNA)

NM_006210
NM_001146184
NM_001146185
NM_001146186
NM_001146187

NM_008817

RefSeq (protein)

NP_001139656
NP_001139657
NP_001139658
NP_001139659
NP_006201

NP_032843

Location (UCSC)Chr 19: 56.81 – 56.84 MbChr 7: 6.7 – 6.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[5][6] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[7] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[8]


Interactions

PEG3 has been shown to interact with SIAH2[9] and SIAH1.[9] kjh-5oil2-*m jhac-*n.,myr0.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198300 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002265 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
  6. ^ "Entrez Gene: PEG3 paternally expressed 3".
  7. ^ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". PLOS ONE. 8 (12): e83359. Bibcode:2013PLoSO...883359K. doi:10.1371/journal.pone.0083359. PMC 3877027. PMID 24391757.
  8. ^ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
  9. ^ a b Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5). UNITED STATES: 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.

Further reading

  • Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555. S2CID 1235332.
  • Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424.
  • Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)". Genomics. 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
  • Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237–47. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267. S2CID 43806250.
  • Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620.
  • Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496. S2CID 29703139.
  • Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806–11. doi:10.4161/cc.4.6.1716. PMID 15908796.
  • Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
  • Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311. S2CID 45211094.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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