F2RL2

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Proteazom-aktivirani receptor 3
Identifikatori
SimboliF2RL2; PAR3
Vanjski IDOMIM: 601919 MGI: 1298208 HomoloGene: 36151 IUPHAR: PAR3 GeneCards: F2RL2 Gene
Ontologija gena
Molekularna funkcija • odopsinu-slična receptorska aktivnost
• aktivnost fosfoinozitid fosfolipaze C
• receptorska aktivnost
• aktivnost trombinskog receptora
Celularna komponenta • membrana plazme
• integralno sa membranom plazme
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• koagulacija krvi
• respons na ranjavanje
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez215114064
EnsemblENSG00000164220ENSMUSG00000021675
UniProtO00254Q3UXV3
RefSeq (mRNA)NM_004101NM_010170
RefSeq (protein)NP_004092NP_034300
Lokacija (UCSC)Chr 5:
75.95 - 75.95 Mb		Chr 13:
96.8 - 96.8 Mb
PubMed pretraga[1][2]

Proteazom-aktivirani receptor 3 (PAR3), ili Receptoru koagulacionog faktora II (trombina) sličan 2, je protein kodiran F2RL2 genom kod ljudi.

F2RL2 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR3 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor. F2RL2 je kofaktor za F2RL3 aktivaciju trombinom. On posreduje trombinom-podstaknutu fosfoinozitid hidrolizu. F2RL2 je izražen u nizu tkiva.[1]

Vidi još

  • Proteazom-aktivirani receptor

Reference

  1. ↑ „Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2”. 

Literatura

  • Hollenberg MD, Compton SJ (2002). „International Union of Pharmacology. XXVIII. Proteinase-activated receptors.”. Pharmacol. Rev. 54 (2): 203–17. DOI:10.1124/pr.54.2.203. PMID 12037136. 
  • Ishihara H, Connolly AJ, Zeng D, et al. (1997). „Protease-activated receptor 3 is a second thrombin receptor in humans.”. Nature 386 (6624): 502–6. DOI:10.1038/386502a0. PMID 9087410. 
  • Schmidt VA, Nierman WC, Maglott DR, et al. (1998). „The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.”. J. Biol. Chem. 273 (24): 15061–8. DOI:10.1074/jbc.273.24.15061. PMID 9614115. 
  • Xu WF, Andersen H, Whitmore TE, et al. (1998). „Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. DOI:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. 
  • Guyonnet Dupérat V, Jacquelin B, Boisseau P, et al. (1998). „Protease-activated receptor genes are clustered on 5q13.”. Blood 92 (1): 25–31. PMID 9639495. 
  • Kahn ML, Zheng YW, Huang W, et al. (1998). „A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. DOI:10.1038/29325. PMID 9716134. 
  • Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). „Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. DOI:10.1074/jbc.273.36.23290. PMID 9722561. 
  • Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). „Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. DOI:10.1172/JCI6042. PMC 408153. PMID 10079109. 
  • Hauck RW, Schulz C, Schömig A, et al. (1999). „alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors.”. Am. J. Physiol. 277 (1 Pt 1): L22–9. PMID 10409227. 
  • Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). „PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. DOI:10.1038/35007085. PMID 10766244. 
  • O'Brien PJ, Prevost N, Molino M, et al. (2000). „Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.”. J. Biol. Chem. 275 (18): 13502–9. DOI:10.1074/jbc.275.18.13502. PMID 10788464. 
  • Cumashi A, Ansuini H, Celli N, et al. (2001). „Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets.”. Thromb. Haemost. 85 (3): 533–8. PMID 11307827. 
  • Sambrano GR, Weiss EJ, Zheng YW, et al. (2001). „Role of thrombin signalling in platelets in haemostasis and thrombosis.”. Nature 413 (6851): 74–8. DOI:10.1038/35092573. PMID 11544528. 
  • Miike S, McWilliam AS, Kita H (2002). „Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. PMID 11714832. 
  • Uehara A, Sugawara S, Muramoto K, Takada H (2002). „Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2.”. J. Immunol. 169 (8): 4594–603. PMID 12370398. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Even-Ram SC, Grisaru-Granovsky S, Pruss D, et al. (2003). „The pattern of expression of protease-activated receptors (PARs) during early trophoblast development.”. J. Pathol. 200 (1): 47–52. DOI:10.1002/path.1338. PMID 12692840. 
  • Owen WG (2003). „PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. DOI:10.1016/S0006-291X(03)00732-0. PMID 12732212. 
  • Tanaka N, Morita T, Nezu A, et al. (2003). „Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1).”. Life Sci. 73 (3): 301–10. DOI:10.1016/S0024-3205(03)00269-8. PMID 12757837. 
  • „Protease-Activated Receptors: PAR3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)