Prostaglandinski E receptor 3

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Prostaglandinski E receptor 3
Identifikatori
SimboliPTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R
Vanjski IDOMIM: 176806 MGI: 97795 HomoloGene: 105703 IUPHAR: EP3 GeneCards: PTGER3 Gene
Ontologija gena
Molekularna funkcija • ligandom aktivirano za sekvencu specifično DNK vezivanje RNK polimeraze II transkriptnog faktora
• aktivnost prostaglandinskog E receptora
Celularna komponenta • nuklearna koverta
• ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • transkripcija, DNK-zavisna
• signalni put G-protein spregnutog receptora
• biološki proces
• ćelijska smrt
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez573319218
EnsemblENSG00000050628ENSMUSG00000040016
UniProtP43115Q6PDF2
RefSeq (mRNA)NM_000957.2NM_011196.2
RefSeq (protein)NP_001119516.1NP_035326.2
Lokacija (UCSC)Chr 1:
71.32 - 71.51 Mb		Chr 3:
157.23 - 157.31 Mb
PubMed pretraga[1][2]

Prostaglandinski E receptor 3 (EP3) je prostaglandinski receptor, kodiran PTGER3 genom.[1]

Receptor

Ovaj protein je član familije G protein spregnutih receptora. On je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). Ovaj receptor ima mnoštvo bioloških funkcija, što obuhvata varenje, nervni sistem, bubrežnu reapsorpciju, i aktivnosti materičnih kontrakcija. U stomaku, on inhibira lučenje želudačne kiseline.

Ispitivanja na miševima sugeriraju da ovaj receptor takođe posreduje odgovor na adrenokortikotropni hormon kao i formiranje groznice.

Varijacije

Više alternativno splajsovanih transkriptnih varijanti kodira osam distinktnih izoformi.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)”. 

Literatura

  • Kotani M, Tanaka I, Ogawa Y i dr.. (1995). „Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions”. Mol. Pharmacol. 48 (5): 869–79. PMID 7476918. 
  • Duncan AM, Anderson LL, Funk CD i dr.. (1995). „Chromosomal localization of the human prostanoid receptor gene family”. Genomics 25 (3): 740–742. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). „Splice variants of the human EP3 receptor for prostaglandin E2”. Eur. J. Biochem. 228 (1): 23–30. DOI:10.1111/j.1432-1033.1995.tb20223.x. PMID 7883006. 
  • An S, Yang J, So SW i dr.. (1995). „Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals”. Biochemistry 33 (48): 14496–14502. DOI:10.1021/bi00252a016. PMID 7981210. 
  • Regan JW, Bailey TJ, Donello JE i dr.. (1994). „Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini”. Br. J. Pharmacol. 112 (2): 377–85. PMC 1910333. PMID 8075855. 
  • Yang J, Xia M, Goetzl EJ, An S (1994). „Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2”. Biochem. Biophys. Res. Commun. 198 (3): 999–1006. DOI:10.1006/bbrc.1994.1142. PMID 8117308. 
  • Kunapuli SP, Fen Mao G, Bastepe M i dr.. (1994). „Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells”. Biochem. J. 298 (2): 263–7. PMC 1137934. PMID 8135729. 
  • Adam M, Boie Y, Rushmore TH i dr.. (1994). „Cloning and expression of three isoforms of the human EP3 prostanoid receptor”. FEBS Lett. 338 (2): 170–174. DOI:10.1016/0014-5793(94)80358-7. PMID 8307176. 
  • Chang C, Negishi M, Nishigaki N, Ichikawa A (1997). „Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype”. Biochem. J. 322 (2): 597–601. PMC 1218231. PMID 9065782. 
  • Kotani M, Tanaka I, Ogawa Y i dr.. (1997). „Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)”. Genomics 40 (3): 425–434. DOI:10.1006/geno.1996.4585. PMID 9073510. 
  • Ushikubi F, Segi E, Sugimoto Y i dr.. (1998). „Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3”. Nature 395 (6699): 281–284. DOI:10.1038/26233. PMID 9751056. 
  • Bhattacharya M, Peri K, Ribeiro-da-Silva A i dr.. (1999). „Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope”. J. Biol. Chem. 274 (22): 15719–15724. DOI:10.1074/jbc.274.22.15719. PMID 10336471. 
  • Liu J, Akahoshi T, Jiang S i dr.. (2000). „Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3”. J. Leukoc. Biol. 68 (2): 187–93. PMID 10947062. 
  • Kurihara Y, Endo H, Kondo H (2001). „Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells”. Inflamm. Res. 50 (1): 1–5. DOI:10.1007/s000110050716. PMID 11235015. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Matsuoka Y, Furuyashiki T, Bito H i dr.. (2003). „Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes”. Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–4137. DOI:10.1073/pnas.0633341100. PMC 153060. PMID 12642666. 
  • Wing DA, Goharkhay N, Hanna M i dr.. (2003). „EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium”. J. Soc. Gynecol. Investig. 10 (3): 124–129. DOI:10.1016/S1071-5576(03)00007-8. PMID 12699873. 
  • Abulencia JP, Gaspard R, Healy ZR i dr.. (2003). „Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells”. J. Biol. Chem. 278 (31): 28388–28394. DOI:10.1074/jbc.M301378200. PMID 12743126. 
  • Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes”. J. Clin. Endocrinol. Metab. 88 (6): 2810–2816. DOI:10.1210/jc.2002-021475. PMID 12788892. 
  • Moreland RB, Kim N, Nehra A i dr.. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum”. Int. J. Impot. Res. 15 (5): 362–368. DOI:10.1038/sj.ijir.3901042. PMID 14562138. 

Vidi još

Spoljašnje veze

  • „Prostanoid Receptors: EP3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-06-29. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)