Galaninski receptor 3
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| Galaninski receptor 3 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GALR3; | ||||||||||
| Vanjski ID | OMIM: 603692 MGI: 1329003 HomoloGene: 20798 IUPHAR: GAL3 GeneCards: GALR3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8484 | 14429 | |||||||||
| Ensembl | ENSG00000128310 | ENSMUSG00000047429 | |||||||||
| UniProt | O60755 | O88853 | |||||||||
| RefSeq (mRNA) | NM_003614 | XM_001001042 | |||||||||
| RefSeq (protein) | NP_003605 | XP_001001042 | |||||||||
| Lokacija (UCSC) | Chr 22: 36.55 - 36.55 Mb | Chr 15: 78.87 - 78.87 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Galaninski receptor 3 (GAL3) je G protein spregnuti receptor kodiran GALR3 genom.[1]
Neuropeptid galanin modulira razne fiziološke procese kao što su kognicija/memorija, bol, hormonska sekrecija, način ishrane. Humani galaninski receptori su G protein-spregnuti receptori koji su funkcionalno spregnuti sa njihovim intracelularnim efektorima putem različitih signalnih puteva. GALR3 je nađen u mnogim tkivima i može da bude izražen kao 1.4-, 2.4-, i 5-kb transkripti.[1]
Vidi još
Reference
Literatura
- Smith KE, Walker MW, Artymyshyn R, et al. (1998). „Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.”. J. Biol. Chem. 273 (36): 23321–6. DOI:10.1074/jbc.273.36.23321. PMID 9722565.
- Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). „Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.”. J. Neurochem. 71 (6): 2239–51. DOI:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121.
- Iismaa TP, Fathi Z, Hort YJ, et al. (1999). „Structural organization and chromosomal localization of three human galanin receptor genes.”. Ann. N. Y. Acad. Sci. 863: 56–63. DOI:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159.
- Lapsys NM, Furler SM, Henderson NK, et al. (1999). „A polymorphism in the human GALR3 galanin receptor gene (GALNR3).”. Mol. Cell. Probes 13 (4): 325–7. DOI:10.1006/mcpr.1999.0254. PMID 10441207.
- Dunham I, Shimizu N, Roe BA, et al. (1999). „The DNA sequence of human chromosome 22.”. Nature 402 (6761): 489–95. DOI:10.1038/990031. PMID 10591208.
- Berger A, Tuechler C, Almer D, et al. (2002). „Elevated expression of galanin receptors in childhood neuroblastic tumors.”. Neuroendocrinology 75 (2): 130–8. DOI:10.1159/000048229. PMID 11867941.
- Belfer I, Hipp H, Bollettino A, et al. (2007). „Alcoholism is associated with GALR3 but not two other galanin receptor genes.”. Genes, Brain and Behavior 6 (5): 473–81. DOI:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.
- Runesson J, Sollenberg UE, Jurkowski W, et al. (2010). „Determining receptor–ligand interaction of human galanin receptor type 3”. Neurochem. Int. 57: 804–811. DOI:10.1016/j.neuint.2010.08.018. PMID 20817064.
Spoljašnje veze
- „Galanin Receptors: GAL3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2019-10-26.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
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Frizzled / Zaglađeni
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
