TFRC
| Transferinski receptor (p90, CD71) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1cx8. | |||||||||||
| Dostupne strukture | |||||||||||
| 1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N | |||||||||||
| Identifikatori | |||||||||||
| Simboli | TFRC; CD71; T9; TFR; TFR1; TR; TRFR; p90 | ||||||||||
| Vanjski ID | OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7037 | 22042 | |||||||||
| Ensembl | ENSG00000072274 | ENSMUSG00000022797 | |||||||||
| UniProt | P02786 | Q62351 | |||||||||
| RefSeq (mRNA) | NM_001128148.1 | NM_011638.4 | |||||||||
| RefSeq (protein) | NP_001121620.1 | NP_035768.1 | |||||||||
| Lokacija (UCSC) | Chr 3: 195.75 - 195.81 Mb | Chr 16: 32.61 - 32.63 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Transferinski receptor 1 (TfR1, Klaster diferencijacije 71, CD71) je protein koji je kod ljudi kodiran TFRC genom.[1][2] TfR1 je neohodan za prenos gvožđa vezanog za transferin u ćelije.[3][4]
Interakcije
TFRC formira interakcije sa GABARAP[5] i HFE.[6][7]
Reference
- ^ Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (1981). „Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin”. Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515—9. PMC 319822
. PMID 6270680. doi:10.1073/pnas.78.7.4515. - ^ Rabin M, McClelland A, Kühn L, Ruddle FH (1985). „Regional localization of the human transferrin receptor gene to 3q26.2----qter”. Am. J. Hum. Genet. 37 (6): 1112—6. PMC 1684729 . PMID 3002171.
- ^ Aisen P (2004). „Transferrin receptor 1”. Int. J. Biochem. Cell Biol. 36 (11): 2137—43. PMID 15313461. doi:10.1016/j.biocel.2004.02.007.
- ^ Moos T (2002). „Brain iron homeostasis”. Danish Medical Bulletin. 49 (4): 279—301. PMID 12553165.
- ^ Green F, O'Hare T, Blackwell A, Enns CA (2002). „Association of human transferrin receptor with GABARAP”. FEBS Lett. 518 (1–3): 101—6. PMID 11997026. doi:10.1016/S0014-5793(02)02655-8.
- ^ Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (1998). „The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding”. Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472—7. PMC 19050 . PMID 9465039. doi:10.1073/pnas.95.4.1472.
- ^ West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (2000). „Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE”. J. Biol. Chem. 275 (49): 38135—8. PMID 11027676. doi:10.1074/jbc.C000664200.
Vidi još
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PDB Galerija
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1cx8: Kristalna struktura ektodomena ljudskog transferinskog receptora -
1de4: Hemohromatozni protein HFE u kompleksu sa transferinskim receptorom -
1suv: Struktura kompleksa ljudskog transferinskog receptora i transferina -
2nsu: Kristalna struktura ektodomena ljudskog transferinskog receptora
